دورية
Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective
| العنوان: | Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective |
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| المؤلفون: | Roof, Robin L., Duvdevani, Revital, Heyburn, John W., Stein, Donald G. |
| المصدر: | Experimental Neurology; April 1996, Vol. 138 Issue: 2 p246-251, 6p |
| مستخلص: | Cerebral edema is a serious side effect of traumatic brain injury. We have previously established that progesterone injections, initiated within 1 h after cortical contusion injury, reduced edema when assessed 3 days later. To determine how rapidly progesterone can reduce edema, male and female rats were given the hormone 1 h after damage to the medial frontal cortex, and edema levels were assessed between 2 h and 7 days postinjury. Progesterone decreased edema within 6 h of the injury and continued to be effective for the duration of treatment. In addition, we assessed whether progesterone injections are effective when delays are imposed between injury and initiation of treatment. Male and female rats received progesterone after postinjury delays of 6, 24, or 48 h. Progesterone was effective in reducing edema when treatment was delayed until 24 h after injury. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00144886 10902430 |
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| DOI: | 10.1006/exnr.1996.0063 |