Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes
| العنوان: | Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes |
|---|---|
| المؤلفون: | Antonio Secchi, Raffaele Di Fenza, Alessandra Petrelli, Francesca Gatti, Paolo Fiorina, M. Carvello |
| المساهمون: | Alessandra, Petrelli, Raffaele Di, Fenza, Michele, Carvello, Francesca, Gatti, Secchi, Antonio, Paolo, Fiorina |
| المصدر: | Experimental Diabetes Research Experimental Diabetes Research, Vol 2012 (2012) |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | lcsh:Internal medicine, lcsh:Specialties of internal medicine, Endocrinology, Diabetes and Metabolism, Cellular differentiation, lcsh:Medicine, Review Article, Biology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Endothelial progenitor cell, Vasculogenesis, lcsh:RC581-951, Diabetes Mellitus, Humans, Progenitor cell, lcsh:RC31-1245, lcsh:RC648-665, Stem Cells, lcsh:R, Endothelial Cells, Cell Differentiation, General Medicine, Vascular endothelial growth factor B, Endothelial stem cell, Vascular endothelial growth factor A, Immunology, Cancer research, Stem cell |
| الوصف: | Bone-marrow-derived cells-mediated postnatal vasculogenesis has been reported as the main responsible for the regulation of vascular homeostasis in adults. Since their discovery, endothelial progenitor cells have been depicted as mediators of postnatal vasculogenesis for their peculiar phenotype (partially staminal and partially endothelial), their ability to differentiate in endothelial cell line and to be incorporated into the vessels wall during ischemia/damage. Diabetes mellitus, a condition characterized by cardiovascular disease, nephropathy, and micro- and macroangiopathy, showed a dysfunction of endothelial progenitor cells. Herein, we review the mechanisms involved in diabetes-related dysfunction of endothelial progenitor cells, highlighting how hyperglycemia affects the different steps of endothelial progenitor cells lifetime (i.e., bone marrow mobilization, trafficking into the bloodstream, differentiation in endothelial cells, and homing in damaged tissues/organs). Finally, we review preclinical and clinical strategies that aim to revert diabetes-induced dysfunction of endothelial progenitor cells as a means of finding new strategies to prevent diabetic complications. |
| تدمد: | 1687-5303 1687-5214 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d511e2a75740ec4fa81bb6bb8b46e33cTest https://doi.org/10.1155/2012/471823Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d511e2a75740ec4fa81bb6bb8b46e33c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16875303 16875214 |
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