Impact of Insulin Resistance on Silent and Ongoing Myocardial Damage in Normal Subjects: The Takahata Study
| العنوان: | Impact of Insulin Resistance on Silent and Ongoing Myocardial Damage in Normal Subjects: The Takahata Study |
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| المؤلفون: | Tetsu Watanabe, Nobuyuki Kiribayashi, Isao Kubota, Tetsuro Shishido, Yoshiyuki Ueno, Takanori Arimoto, Satoshi Nishiyama, Shinpei Kadowaki, Taro Narumi, Takamasa Kayama, Takeo Kato, Takehiko Miyashita, Hiroki Takahashi, Yoko Shibata, Tsuneo Konta, Takuya Miyamoto |
| المصدر: | Experimental Diabetes Research, Vol 2012 (2012) Experimental Diabetes Research |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, lcsh:Medicine, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Japan, Natriuretic Peptide, Brain, Mass Screening, Aged, 80 and over, Metabolic Syndrome, Sex Characteristics, education.field_of_study, Incidence, Metabolic disorder, Age Factors, General Medicine, Middle Aged, Hypertension, Cardiology, Female, medicine.symptom, Cardiomyopathies, Fatty Acid Binding Protein 3, Adult, medicine.medical_specialty, lcsh:Internal medicine, Article Subject, lcsh:Specialties of internal medicine, Population, Fatty Acid-Binding Proteins, Asymptomatic, Insulin resistance, lcsh:RC581-951, Internal medicine, medicine, Humans, education, lcsh:RC31-1245, Mass screening, Aged, lcsh:RC648-665, business.industry, lcsh:R, Odds ratio, medicine.disease, Cross-Sectional Studies, Early Diagnosis, Endocrinology, Heart failure, Clinical Study, Insulin Resistance, Metabolic syndrome, business, Biomarkers |
| الوصف: | Background. Insulin resistance (IR) is part of the metabolic syndrome (Mets) that develops after lifestyle changes and obesity. Although the association between Mets and myocardial injury is well known, the effect of IR on myocardial damage remains unclear.Methods and Results. We studied 2200 normal subjects who participated in a community-based health check in the town of Takahata in northern Japan. The presence of IR was assessed by homeostasis model assessment ratio, and the serum level of heart-type fatty acid binding protein (H-FABP) was measured as a maker of silent and ongoing myocardial damage. H-FABP levels were significantly higher in subjects with IR and Mets than in those without metabolic disorder regardless of gender. Multivariate logistic analysis showed that the presence of IR was independently associated with latent myocardial damage (odds ratio: 1.574, 95% confidence interval 1.1–2.3) similar to the presence of Mets.Conclusions. In a screening of healthy subjects, IR and Mets were similarly related to higher H-FABP levels, suggesting that there may be an asymptomatic population in the early stages of metabolic disorder that is exposed to myocardial damage and might be susceptible to silent heart failure. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1687-5303 1687-5214 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784411f5708b402410f0931950abaabeTest https://doaj.org/article/538dcdc1de674530b5b6ee49be089f8aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....784411f5708b402410f0931950abaabe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16875303 16875214 |
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