The 5‐HT1Areceptor agonist, 8‐OH‐DPAT, attenuates long‐lasting pain in imiquimod‐induced psoriasis in mice
| العنوان: | The 5‐HT1Areceptor agonist, 8‐OH‐DPAT, attenuates long‐lasting pain in imiquimod‐induced psoriasis in mice |
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| المؤلفون: | Miguel Avalos-Viveros, Claudia Cervantes-Durán, Alain-Raimundo Rodríguez-Orozco, Luz Torner, Héctor-Eduardo Martínez-Flores, Sandra-Guadalupe Sánchez-Ceja, Martha Estrella García-Pérez |
| المصدر: | Experimental Dermatology. 31:600-607 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Agonist, 8-OH-DPAT, business.industry, medicine.drug_class, Dermatology, Pharmacology, Serotonergic, medicine.disease, Biochemistry, chemistry.chemical_compound, Nociception, Allodynia, chemistry, Psoriasis, Hyperalgesia, Medicine, medicine.symptom, business, Molecular Biology, 5-HT receptor |
| الوصف: | Psoriasis pain is a common symptom underestimated and rarely evaluated in psoriasis clinical trials. This work aimed to investigate whether the development of secondary chronic allodynia and hyperalgesia in the imiquimod (IMQ)-induced psoriasis mice model could be modulated by anti-inflammatory agents and compound 48/80 (C48/80) and to determine whether the activation of 5-HT1A receptor modulates these nociceptive behaviours. C57BL/6 male mice were treated with 5% IMQ for 7 days. The paw withdrawal responses to von Frey filaments (10 and 250 mN) were used to assess the allodynia and hyperalgesia. Nociceptive behaviours were also evaluated using ketorolac 15 mg/kg s.c., adalimumab 10 mg/kg s.c. and C48/80 10 mg/kg i.p. Then, the serum serotonin and the impact of 8-OH-DPAT (1 mg/kg s.c), a 5-HT1A receptor agonist, on long-lasting pain were examined. Mice receiving IMQ showed enhanced nociception, which decreased with all tested compounds. The serum serotonin in the IMQ group showed a significant decrease (947.042 ng/ml) regarding the control group (1143.68 ng/ml). The pretreatment with 8-OH-DPAT alleviated pain-related behaviours. These results suggest that the long-lasting pain resulting from psoriasis inflammation is also associated with the serotonergic system. The 5-HT1A receptor should be further explored as a potential therapeutic target for psoriasis pain modulation. |
| تدمد: | 1600-0625 0906-6705 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ab246fd827f17c2588276cfa649c29f0Test https://doi.org/10.1111/exd.14492Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........ab246fd827f17c2588276cfa649c29f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000625 09066705 |
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