Multiplex immunoassay measurement of amyloid-β42 to amyloid-β40 ratio in plasma discriminates between dementia due to Alzheimer’s disease and dementia not due to Alzheimer’s disease
| العنوان: | Multiplex immunoassay measurement of amyloid-β42 to amyloid-β40 ratio in plasma discriminates between dementia due to Alzheimer’s disease and dementia not due to Alzheimer’s disease |
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| المؤلفون: | Jonathan Vogelgsang, Rebekka Vogelgsang, Jens Wiltfang, Hedieh Shahpasand-Kroner, Ruth Vukovich, Frank Streit |
| المصدر: | Experimental brain research 236(5), 1241-1250 (2018). doi:10.1007/s00221-018-5210-x |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Neurology, Neuropathology, Gastroenterology, Diagnosis, Differential, 03 medical and health sciences, blood [Alzheimer Disease], Sex Factors, 0302 clinical medicine, Cerebrospinal fluid, Internal medicine, blood [Amyloid beta-Peptides], medicine, Humans, Dementia, ddc:610, Aged, Aged, 80 and over, blood [Biomarkers], Amyloid beta-Peptides, business.industry, methods [Immunoassay], General Neuroscience, diagnosis [Alzheimer Disease], amyloid beta-protein (1-40), Middle Aged, amyloid beta-protein (1-42), medicine.disease, blood [Dementia], Peptide Fragments, diagnosis [Dementia], 030104 developmental biology, blood [Peptide Fragments], Biomarker (medicine), Female, Liver function, Alzheimer's disease, business, Biomarkers, 030217 neurology & neurosurgery, Blood sampling |
| الوصف: | The cerebrospinal fluid (CSF) biomarkers amyloid-β42 (Aβ42), total Tau, and phospho-181-Tau represent important diagnostic tools to support the clinical diagnosis of Alzheimer's disease (AD). Acquiring CSF by lumbar puncture is considered a moderately invasive procedure, while blood sampling is minimally invasive with calculable risks and can be performed by trained non-medical staff. Thus, the identification of reliable and robust blood biomarkers of AD-related neuropathology would be significantly advantageous in daily practice and would allow more patients to be screened. In this study, we performed a multiplex amyloid-β assay to simultaneously measure Aβ40 and Aβ42. We analyzed how well Aβ40, Aβ42, and the Aβ42 to Aβ40 ratio (Aβ42/40) could differentiate between patients suffering from dementia either due or not due to AD. In addition, we studied different factors affecting Aβ levels in plasma. Plasma Aβ42/40 level was significantly lower in patients with dementia due to AD than in those with dementia due to other causes. Aβ42/40 correlated weakly between plasma and CSF, but did not differ between amyloid-PET positive or negative patients. Furthermore, we found that kidney function influences Aβ40 and Aβ42 plasma levels, but not Aβ42/40 level. Liver function, age, and sex do not affect Aβ levels in plasma. |
| تدمد: | 1432-1106 0014-4819 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ef8b0b3a53f6466c0f3074d80a7987Test https://doi.org/10.1007/s00221-018-5210-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....92ef8b0b3a53f6466c0f3074d80a7987 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321106 00144819 |
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