Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone-induced benign prostatic hyperplasia in rats
| العنوان: | Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone-induced benign prostatic hyperplasia in rats |
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| المؤلفون: | Dan‑Ming Peng, Li‑Li Jin, Bi‑Cheng Yang, Yi‑Fang Yang, Kun Li |
| المصدر: | Experimental and Therapeutic Medicine |
| بيانات النشر: | Spandidos Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, urologic and male genital diseases, Immunology and Microbiology (miscellaneous), Prostate, Lower urinary tract symptoms, Internal medicine, Medicine, Testosterone, benign prostatic hyperplasia, Oncogene, urogenital system, business.industry, rape pollen, Articles, General Medicine, Hyperplasia, medicine.disease, Molecular medicine, Fluid extract, medicine.anatomical_structure, Endocrinology, cyclooxygenase-2, Apoptosis, 5α-reductase, business |
| الوصف: | Benign prostatic hyperplasia (BPH) can lead to lower urinary tract symptoms. Rape pollen is an apicultural product that is composed of nutritionally valuable and biologi- cally active substances. The aim of the present study was to investigate the protective effect of rape pollen supercritical CO2 fluid extract (SFE-CO2) in BPH development using a testosterone-induced BPH rat model. BPH was induced in the experimental groups by daily subcutaneous injections of testosterone for a period of 30 days. Rape pollen SFE-CO2 was administered daily by oral gavage concurrently with the testosterone injections. Animals were sacrificed at the sched - uled termination and the prostates were weighed and subjected to histopathological examination. Testosterone, dihydrotestos- terone (DHT), 5α-reductase and cyclooxygenase-2 (COX-2) levels were also measured. BPH-induced animals exhibited an increase in prostate weight with increased testosterone, DHT, 5α-reductase and COX-2 expression levels. However, rape pollen SFE-CO2 treatment resulted in significant reductions in the prostate index and testosterone, DHT, 5α-reductase and COX-2 levels compared with those in BPH-induced animals. Histopathological examination also demonstrated that rape pollen SFE-CO2 treatment suppressed testosterone-induced BPH. These observations indicate that rape pollen SFE-CO2 inhibits the development of BPH in rats and these effects are closely associated with reductions in DHT, 5α-reductase and COX-2 levels. Therefore, the results of the present study clearly indicate that rape pollen SFE-CO2 extract may be a useful agent in BPH treatment. |
| تدمد: | 1792-1015 1792-0981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9808e094c5b9ec1d40da12cdb890bcTest https://doi.org/10.3892/etm.2014.1680Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8e9808e094c5b9ec1d40da12cdb890bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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