Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow
| العنوان: | Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow |
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| المؤلفون: | Zhenzhen Wei, Danyan Jia, Jian He, Yanling Zhang, Hongmei Niu |
| المصدر: | Experimental and Therapeutic Medicine |
| بيانات النشر: | Spandidos Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, chest pain, Atorvastatin, Inflammation, 030204 cardiovascular system & hematology, Chest pain, Endothelial progenitor cell, 03 medical and health sciences, 0302 clinical medicine, circulating endothelial progenitor cells, Immunology and Microbiology (miscellaneous), Internal medicine, medicine, business.industry, Interleukin, Articles, General Medicine, Molecular medicine, ET-1, coronary flow, Endocrinology, inflammation, Apoptosis, Cardiology, lipids (amino acids, peptides, and proteins), medicine.symptom, business, 030217 neurology & neurosurgery, TIMI, medicine.drug |
| الوصف: | The underlying mechanisms behind the effect of atorvastatin on patients with coronary slow flow (CSF) remain largely unknown. To investigate the possible underlying molecular mechanisms 108 patients were divided into atorvastatin group and control group. Coronary flow was quantified according to corrected TIMI frame count (CTFC). Serum high sensitivity C-reactive protein (hs-CRP), lipids, ET-1, interleukin (IL)-6, NO, circulating endothelial progenitor cell (cEPC) count, adhesion, migration and proliferation were measured in pretreatment and post-treatment. After respective treatment, the atorvastatin group had significantly decreased levels of TC, TG, LDL-C, hs-CRP, ET-1 and IL-6 and increased NO compared to the control group. The atorvastatin group had a more significant improvement of CTFC, effective rate, cEPC number, EPC adhesion, migration and proliferation compared to the control group. In conclusion, atorvastatin can be used in treatment of CSF by suppressing inflammation and improving endothelial function. |
| تدمد: | 1792-1015 1792-0981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e3978be5e8df5e98c45823a16a729fTest https://doi.org/10.3892/etm.2017.5484Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59e3978be5e8df5e98c45823a16a729f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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