Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination
| العنوان: | Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination |
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| المؤلفون: | Karin Kanc, Vedran Savić, Mojca Lunder, Miodrag Janić, Barbara Eržen, Andrej Janež, Mišo Šabovič |
| المصدر: | Experimental and Therapeutic Medicine. 10:1207-1211 |
| بيانات النشر: | Spandidos Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, business.industry, Articles, General Medicine, medicine.disease, Placebo, Discontinuation, Surgery, Immunology and Microbiology (miscellaneous), Valsartan, Internal medicine, Diabetes mellitus, medicine.artery, Cardiology, Medicine, In patient, Brachial artery, business, Pulse wave velocity, Fluvastatin, medicine.drug |
| الوصف: | Improvement of arterial wall (AW) characteristics decreases cardiovascular risk. In a previous study, it was observed that AW characteristics in patients with diabetes mellitus type 1 are significantly improved by short-term treatment with a low-dose combination of fluvastatin and valsartan. Additionally, a unique phenomenon of prolonged effect after treatment discontinuation was suggested. The present study tested whether repeated treatm ent after a certain period results in the same beneficial effect, th ereby advancing the hypothesis that cyclic treatment can provide a long-term improvement of AW characteristics. A total of 44 patients with diabetes mellitus type 1 that participated in the previous study were recruited. Six months after the discontinuation of the initial treatment, the same treatment with a low-dose fluvastatin (10 mg daily) and valsartan (20 mg daily) combination (n=22) or placebo (n=22) was repeated. Brachial artery flow-mediated dilation (FMD), pulse wave velocity (PWV) and carotid artery β-stiffness were measured. It was found that the beneficial effect achieved with an initial 1-month treatment was completely regained following treatment repetition: FMD improved by 50.9% (P |
| تدمد: | 1792-1015 1792-0981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e141c7281ce2673093d5012c3fa582Test https://doi.org/10.3892/etm.2015.2622Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9e141c7281ce2673093d5012c3fa582 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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