Tolerogenic dendritic cells suppress titanium particle‑induced inflammation
| العنوان: | Tolerogenic dendritic cells suppress titanium particle‑induced inflammation |
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| المؤلفون: | Bing Han, Wenzhao Wang, Mingjie Sun, Jianan Chen, Huichao Tian, Wei Xie, Yunpeng Jiang |
| المصدر: | Experimental and Therapeutic Medicine |
| بيانات النشر: | Spandidos Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Inflammatory arthritis, Cell, Inflammation, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunology and Microbiology (miscellaneous), medicine, Oncogene, business.industry, Articles, General Medicine, medicine.disease, Molecular medicine, air-pouch model, In vitro, 030104 developmental biology, medicine.anatomical_structure, inflammation, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, titanium particle, tolDCs, medicine.symptom, business |
| الوصف: | Aseptic loosening is a major complication of prosthetic joint surgery. The leading cause of arthroplasty failure is particulate wear debris such as titanium particles. Dendritic cells (DCs) are one type of immune cells that play an important role in the initiation and progression of inflammatory processes. DCs can develop into tolerogenic DCs (tolDCs), which present an alternative therapeutic strategy for inflammatory disorders. Previously, antigen-specific tolDCs were generated, which showed a promising effect in treating inflammatory arthritis and immune thrombocytopenia. The present study reports that tolDCs effectively inhibited titanium particle-induced inflammation in an air-pouch mouse model by decreasing pro-inflammatory cytokines. In addition, a mechanistic study demonstrated that tolDCs significantly protected against titanium particle-induced inflammatory processes in vitro by releasing anti-inflammatory cytokines, such as interleukin-10. Collectively, these findings not only demonstrate that tolDCs play an important role in inhibiting titanium particle-induced inflammation but also provide a potential alternative for the prevention or treatment of titanium particle-induced inflammation. |
| تدمد: | 1792-1015 1792-0981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a673d7dc612558977291b02b04516beTest https://doi.org/10.3892/etm.2021.10144Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a673d7dc612558977291b02b04516be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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