Effects of Donor Age and Ischemia Time on Outcome After Heart Transplant: A 10-Year Single-Center Experience
| العنوان: | Effects of Donor Age and Ischemia Time on Outcome After Heart Transplant: A 10-Year Single-Center Experience |
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| المؤلفون: | Payam Akhyari, Arash Mehdiani, Udo Boeken, Igor Tudorache, Artur Lichtenberg, Charlotte Boettger, Moritz Benjamin Immohr, Ralf Westenfeld, Hannan Dalyanoglu, Hug Aubin |
| المصدر: | Experimental and Clinical Transplantation. 19:351-358 |
| بيانات النشر: | Baskent University, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Time Factors, Ischemia, Primary Graft Dysfunction, Single Center, Donor age, law.invention, law, medicine, Humans, cardiovascular diseases, Retrospective Studies, Transplantation, business.industry, Gold standard, Age Factors, Perioperative, Middle Aged, medicine.disease, Intensive care unit, Tissue Donors, Treatment Outcome, Anesthesia, Heart failure, Heart Transplantation, Tissue Preservation, business |
| الوصف: | OBJECTIVES In heart failure patients, heart transplant still remains the gold standard of care. Controversy prevails whether organs from older donors or with expected prolonged ischemia times may be accepted for transplant. MATERIALS AND METHODS Between 2010 and 2020, a total of 149 patients underwent heart transplant at our department. In a retrospective analysis, 4 different groups were defined according to donor age and total ischemia time. The younger group with short ischemia time consisted of 62 donors age < 50 years and total ischemia time < 240 minutes; the younger group with long ischemia time consisted of 32 donors age < 50 years and total ischemia time ≥ 240 minutes; the older group with short ischemia time consisted of 43 donors age ≥ 50 years and total ischemia time < 240 minutes; and the older group with long ischemia time consisted of 12 donors age ≥ 50 years and total ischemia time ≥ 240 minutes. RESULTS Prolonged total ischemia time increased the risk of primary graft dysfunction (P = .02) and perioperative neurological events (P = .04). In contrast, there were no differences regarding durations of intensive care unit stay and hospital stay, perioperative bleeding, and renal failure. Although the younger donor age group showed excellent short-term survival (30-day survival rates of 97% for the younger group with short ischemia time and 91% for the younger group with long ischemia time), short-term and mid-term survival rates were impaired in patients with prolonged total ischemia time and older donor age (P = .02). CONCLUSIONS Our results indicate that, in younger donors, prolonged ischemia times may be acceptable. However, in donors older than 50 years, the decision for acceptance as a donor should be made with great caution if the presumed ischemia time exceeds 4 hours. |
| تدمد: | 2146-8427 1304-0855 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747a467cc135bb1ebd91484cde77d3ffTest https://doi.org/10.6002/ect.2020.0279Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....747a467cc135bb1ebd91484cde77d3ff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21468427 13040855 |
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