Inflammatory Status is Different in Relationship to Insulin Resistance in Severely Obese People and Changes after Bariatric Surgery or Diet-induced Weight Loss
| العنوان: | Inflammatory Status is Different in Relationship to Insulin Resistance in Severely Obese People and Changes after Bariatric Surgery or Diet-induced Weight Loss |
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| المؤلفون: | A. Nuñez-Alonso, J.-L. Olcoz-Goñi, R. Diez-Rodríguez, S. Calleja, Isidoro Cano-Rodríguez, María D. Ballesteros-Pomar, Alicia Calleja-Fernández, Alfonso Vidal-Casariego |
| المصدر: | Experimental and Clinical Endocrinology & Diabetes. 122:592-596 |
| بيانات النشر: | Georg Thieme Verlag KG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Calorie, Diet, Reducing, Endocrinology, Diabetes and Metabolism, food.diet, Bariatric Surgery, Proinflammatory cytokine, Young Adult, Endocrinology, food, Insulin resistance, Weight loss, Internal medicine, Weight Loss, Internal Medicine, medicine, Humans, Obesity, Aged, Inflammation, business.industry, General Medicine, Middle Aged, medicine.disease, Lymphocyte Subsets, Surgery, Very low calorie diet, Treatment Outcome, Female, Insulin Resistance, medicine.symptom, business, Homeostasis, CD8, Follow-Up Studies |
| الوصف: | Aim: To assess if insulin resistance is related to a different inflammatory status (especially lymphocyte subpopulations) in severely obese people and to evaluate changes after weight loss either following a very-low calorie diet (VLCD) or bariatric surgery. Research Methods & Procedures: Severely obese patients were consecutively recruited in our Obesity Unit. Blood lymphocyte subpopulations and inflammatory parameters were measured baseline, after a VLCD during 6 weeks and one year after biliopancreatic diversion. Insulin resistance was evaluated by Homeostasis Model Assessment (HOMA) index. Results: After excluding diabetic patients, 58 patients were studied. HOMA index classified 63.8% of them as insulin resistant (IR). Serum baseline levels of inflammatory cytokines were not significantly different between IR and insulinsensitive (IS) patients but, regarding lymphocyte subpopulations, Natural Killer (NK) cells were higher in IR patients [(305.0 (136.7) vs. 235.0 (80.7) cells/µL, p=0.047]. NK cells showed a significant positive correlation with HOMA index (r=0.484, p=0.000) and with the carbohydrate content of the diet (r=0.420, p=0.001). After VLCD, NK cells significantly decreased, but only in IR patients and in those losing more than 10% of their initial weight. After biliopancreatic diversion, total and CD8 T Lymphocytes, B lymphocytes and NK cells also decreased but only in IR individuals. Conclusion: NK cells are significantly increased in IR severely obese people in respect to IS, suggesting a slightly different immune status in these patients with a probable dietary relationship. Weight loss could reverse this increase either after VLCD or after bariatric surgery. |
| تدمد: | 1439-3646 0947-7349 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46465d5be2436457d9e644a8dff8cbcTest https://doi.org/10.1055/s-0034-1382035Test |
| رقم الانضمام: | edsair.doi.dedup.....c46465d5be2436457d9e644a8dff8cbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14393646 09477349 |
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