Efficacy and Safety of Maxing Xianchang Su in the Treatment of Functional Constipation: A Randomized Controlled Trial
| العنوان: | Efficacy and Safety of Maxing Xianchang Su in the Treatment of Functional Constipation: A Randomized Controlled Trial |
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| المؤلفون: | Lijuan Zhao, Lijiang Ji, Hua Huang, Li Ma, Jun Sun, Mi Li, Fenying Lu, Jun Wei, Wen Zhang |
| المصدر: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Article Subject, business.industry, medicine.disease, law.invention, Other systems of medicine, Complementary and alternative medicine, Randomized controlled trial, law, Internal medicine, medicine, Functional constipation, business, RZ201-999, Research Article |
| الوصف: | Background. Functional constipation (FC) is one of the prevalent gastrointestinal disorders that affect people of all ages. Long-term FC has significant effects on the quality of life of patients. Although commonly used drugs have reliable short-term effects, they are easily addictive and have side effects. Therefore, pursuing a convenient drug-food homogenous program is critical for FC patients. Maxing Xianchang Su is a functional food based on traditional Chinese medicine. To investigate the efficacy and safety of Maxing Xianchang Su in FC treatment, we conducted a randomized controlled trial. Methods. We carried out a prospective multicenter randomized parallel controlled study in three hospitals in Jiangsu Province, China, from January 2020 to March 2021, which included 206 FC patients. All patients were arbitrarily assigned into a treatment group and a control group at a ratio of 1 : 1; 103 cases in each group. The treatment group was given oral Maxing Xianchang Su, whereas the control group was treated with lactulose oral solution. The course of treatment was two weeks. The two groups of patients were evaluated after six weeks for symptom improvement before and after taking the drug. Furthermore, the safety of Maxing Xianchang Su was assessed. Results. Both groups of patients successfully completed the study without shedding cases. The effective rates of the treatment group and control group after two weeks were 90.6% and 67.0%, respectively. The treatment group had a better curative effect than the control group ( P < 0.05 ). The symptom score of the two groups improved compared with that before the treatment. The difference between the two groups was statistically significant ( P < 0.05 ). During the treatment process, neither group experienced abnormal changes in blood lipid, blood glucose, routine hematuria, or liver and kidney functions. There were no adverse reactions in both groups. Conclusion. Maxing Xianchang Su has a positive effect on FC treatment with reliable mid-term effect and a high level of safety. |
| وصف الملف: | text/xhtml |
| تدمد: | 1741-4288 1741-427X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6cf2d5cb55fad989df7c7a308f1dd6Test https://doi.org/10.1155/2021/3685440Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d6cf2d5cb55fad989df7c7a308f1dd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
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