Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells
| العنوان: | Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells |
|---|---|
| المؤلفون: | Ganesh Chandra Jagetia, Shaival Kamalaksha Rao |
| المصدر: | Evidence-based Complementary and Alternative Medicine Evidence-Based Complementary and Alternative Medicine, Vol 3, Iss 2, Pp 267-272 (2006) |
| بيانات النشر: | Oxford University Press, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Pharmacology, Tinospora cordifolia, HeLa, Lipid peroxidation, chemistry.chemical_compound, Lactate dehydrogenase, TBARS, Cytotoxic T cell, Medicine, Dichloromethane, Traditional medicine, biology, business.industry, glutathione-S-transferase, lactate dehydrogenase, lipid peroxidation, lcsh:Other systems of medicine, Original Articles, biology.organism_classification, lcsh:RZ201-999, Complementary and alternative medicine, chemistry, Guduchi, cytotoxicity, business |
| الوصف: | Extracts ofTinospora cordifolia(TCE) have been shown to possess anti-tumor properties, but the mechanism of the anti-tumor function of TCE is poorly understood. This investigation elucidates the possible mechanism underlying the cytotoxic effects of dichlormethane extracts of TCE, after selecting optimal duration and concentration for treatment. HeLa cells were exposed to various concentrations of TCE, which has resulted in a concentration-dependent decline in the clonogenicity, glutathione-S-transferase (GST) activity and a concentration-dependent increase in lipid peroxidation (TBARS) with a peak at 4 h and lactate dehydrogenase (LDH) release with a peak at 2 h. Our results suggest that the cytotoxic effect of TCE may be due to lipid peroxidation and release of LDH and decline in GST. |
| اللغة: | English |
| تدمد: | 1741-4288 1741-427X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee02fd4bce17ffc820e300438324c1aTest http://europepmc.org/articles/PMC1475936Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fee02fd4bce17ffc820e300438324c1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
|---|