Influence of Age and Geography on Chemical Composition of 98043 Urinary Stones from the USA
| العنوان: | Influence of Age and Geography on Chemical Composition of 98043 Urinary Stones from the USA |
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| المؤلفون: | Anika Jain, Hemendra N. Shah, Oleksandr N. Kryvenko, Madhumita Parmar, Glenn W. Austin, Nicholas Smith, Jonathan Katz, Nachiketh Soodana-Prakash |
| المصدر: | European Urology Open Science, Vol 34, Iss, Pp 19-26 (2021) European Urology Open Science |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | calcium phosphate stone, Epidemiology, Urology, Urinary system, Calcium oxalate, chemistry.chemical_element, Calcium, chemistry.chemical_compound, Animal science, Urolithiasis, Calcium oxalate stone, stone analysis, Stone composition, Chemical composition, RC254-282, Incidence (epidemiology), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, stone composition, Diseases of the genitourinary system. Urology, Uric acid stones, chemistry, struvite stone, Stone Disease, Uric acid, RC870-923, CALCIUM OXALATE MONOHYDRATE |
| الوصف: | Take Home Message In this report, we examined the incidence of urinary stones in the USA and categorized their frequency based on chemical composition. We found that calcium oxalate made up ~80% of overall stones, of which almost 50% were pure calcium oxalate monohydrate. We also found that age and geographical region were significantly associated with variations in stone composition. Background Urolithiasis is a growing issue globally, but it is heterogeneous, with a different epidemiology and pathophysiology for each different stone composition. Objective The purpose of this study is to describe the incidence of urinary stones in the USA from 2016 to 2019 by chemical composition and to investigate the influence of age and geography on these stone types. Design, setting, and participants We obtained compositional analyses for all urinary stones submitted to a national laboratory over an approximately 3-yr period. Outcome measurements and statistical analysis Data collected included the chemical constituents of a stone, patient age, and geographical origin. We describe the incidence of each stone type by frequency. Statistical testing was performed to determine the influence of age and geographical region on overall incidence of each stone composition. Results and limitations In total, 99 908 specimens were analyzed. When pure stones were ordered by frequency, we found that the most common stone type was calcium oxalate (CaOx) (79.2%), followed by uric acid (UA; 14.3%), calcium phosphate (CaPO4; 3.7%), cystine (0.51%), drug induced (0.12%), and magnesium ammonium phosphate (0.04%). CaOx, UA, and CaPO4 were often mixed with one another. Among CaOx stones, the plurality (28.0%) was made of pure calcium oxalate monohydrate (COM), and only 0.002% was pure calcium oxalate dihydrate. There was an overall association between stone composition and both geographical distribution and age (p < 0.001). Conclusions CaOx stones comprise the majority of urinary stones in the USA, of which almost 28% were pure COM. Additionally, age and geographical region are significantly associated with variations in stone composition. Patient summary We evaluated the incidence of urinary stones in the USA based on their chemical composition. The most common stone type was calcium oxalate, the majority of which was pure calcium oxalate monohydrate. We also found age and geographical region to be significantly associated with variations in stone composition. |
| اللغة: | English |
| تدمد: | 2666-1683 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036bc6be980af7ae9c7fa8e20b1b61daTest http://www.sciencedirect.com/science/article/pii/S266616832101692XTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....036bc6be980af7ae9c7fa8e20b1b61da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26661683 |
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