Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial
| العنوان: | Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial |
|---|---|
| المؤلفون: | Philip A.J. Crosbie, Rhian Gabe, Irene Simmonds, Neil Hancock, Panos Alexandris, Martyn Kennedy, Suzanne Rogerson, David Baldwin, Richard Booton, Claire Bradley, Mike Darby, Claire Eckert, Kevin N. Franks, Jason Lindop, Sam M. Janes, Henrik Møller, Rachael L. Murray, Richard D. Neal, Samantha L. Quaife, Sara Upperton, Bethany Shinkins, Puvan Tharmanathan, Matthew E.J. Callister |
| المصدر: | European Respiratory Journal. 60:2200483 |
| بيانات النشر: | European Respiratory Society (ERS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Lung Neoplasms, Humans, Mass Screening, Tomography, X-Ray Computed, Lung, Early Detection of Cancer |
| الوصف: | BackgroundScreening with low-dose computed tomography (LDCT) reduces lung cancer mortality; however, the most effective strategy for optimising participation is unknown. Here we present data from the Yorkshire Lung Screening Trial, including response to invitation, screening eligibility and uptake of community-based LDCT screening.MethodsIndividuals aged 55–80 years, identified from primary care records as having ever smoked, were randomised prior to consent to invitation to telephone lung cancer risk assessment or usual care. The invitation strategy included general practitioner endorsement, pre-invitation and two reminder invitations. After telephone triage, those at higher risk were invited to a Lung Health Check (LHC) with immediate access to a mobile CT scanner.ResultsOf 44 943 individuals invited, 50.8% (n=22 815) responded and underwent telephone-based risk assessment (16.7% and 7.3% following first and second reminders, respectively). A lower response rate was associated with current smoking status (adjusted OR 0.44, 95% CI 0.42–0.46) and socioeconomic deprivation (adjusted OR 0.58, 95% CI 0.54–0.62 for the mostversusthe least deprived quintile). Of those responding, 34.4% (n=7853) were potentially eligible for screening and offered a LHC, of whom 86.8% (n=6819) attended. Lower uptake was associated with current smoking status (adjusted OR 0.73, 95% CI 0.62–0.87) and socioeconomic deprivation (adjusted OR 0.78, 95% CI 0.62–0.98). In total, 6650 individuals had a baseline LDCT scan, representing 99.7% of eligible LHC attendees.ConclusionsTelephone risk assessment followed by a community-based LHC is an effective strategy for lung cancer screening implementation. However, lower participation associated with current smoking status and socioeconomic deprivation underlines the importance of research to ensure equitable access to screening. |
| وصف الملف: | application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 1399-3003 0903-1936 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d0a24a2c32b57f3f5bd316ce57278eTest https://doi.org/10.1183/13993003.00483-2022Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61d0a24a2c32b57f3f5bd316ce57278e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993003 09031936 |
|---|