التفاصيل البيبلوغرافية
| العنوان: |
Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results. |
| المؤلفون: |
Taouli, Bachir, Hoshida, Yujin, Kakite, Suguru, Chen, Xintong, Tan, Poh, Sun, Xiaochen, Kihira, Shingo, Kojima, Kensuke, Toffanin, Sara, Fiel, M., Hirschfield, Hadassa, Wagner, Mathilde, Llovet, Josep, Tan, Poh Seng, Fiel, M Isabel, Llovet, Josep M |
| المصدر: |
European Radiology; Nov2017, Vol. 27 Issue 11, p4472-4481, 10p, 3 Diagrams, 4 Charts |
| مصطلحات موضوعية: |
LIVER cancer, PHENOTYPES, GENOMICS, COMPUTED tomography, TUMOR markers, HEPATOCELLULAR carcinoma, LIVER tumors, RESEARCH funding, RETROSPECTIVE studies, GENE expression profiling |
| مستخلص: |
Objectives: In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC).Methods: Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis.Results: Thirty-nine HCC tumours (mean size 5.7 ± 3.2 cm) were assessed. Significant positive associations were observed between certain imaging traits and gene signatures of aggressive HCC phenotype (G3-Boyault, Proliferation-Chiang profiles, CK19-Villanueva, S1/S2-Hoshida) with odds ratios ranging from 4.44-12.73 (P <0.045). Infiltrative pattern at imaging was significantly associated with signatures of microvascular invasion and aggressive phenotype. Significant but weak associations were also observed between each enhancement ratio and tumour-to-liver contrast ratios and certain gene expression profiles.Conclusions: This preliminary study demonstrates a correlation between phenotypic imaging traits with gene signatures of aggressive HCC, which warrants further prospective validation to establish imaging-based surrogate markers of molecular phenotypes in HCC.Key Points: • There are associations between imaging and gene signatures of aggressive hepatocellular carcinoma. • Infiltrative type is associated with gene signatures of microvascular invasion and aggressiveness. • Infiltrative type may be a surrogate marker of microvascular invasion gene signature. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
