التفاصيل البيبلوغرافية
| العنوان: |
Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium. |
| المؤلفون: |
Hafezi-Nejad, Nima, Guermazi, Ali, Roemer, Frank, Hunter, David, Dam, Erik, Zikria, Bashir, Kwoh, C., Demehri, Shadpour, Roemer, Frank W, Hunter, David J, Dam, Erik B, Kwoh, C Kent |
| المصدر: |
European Radiology; Feb2017, Vol. 27 Issue 2, p464-473, 10p |
| مصطلحات موضوعية: |
CARTILAGE, OSTEOARTHRITIS, KNEE, TIBIA, FEMUR, ARTICULAR cartilage, KNEE diseases, MAGNETIC resonance imaging, PATELLA, LOGISTIC regression analysis, PREDICTIVE tests, CASE-control method, DISEASE progression |
| مستخلص: |
Objectives: Investigating the association between baseline cartilage volume measurements (and initial 24th month volume loss) with medial compartment Joint-Space-Loss (JSL) progression (>0.7 mm) during 24-48th months of study.Methods: Case and control cohorts (Biomarkers Consortium subset from the Osteoarthritis Initiative (OAI)) were defined as participants with (n=297) and without (n=303) medial JSL progression (during 24-48th months). Cartilage volume measurements (baseline and 24th month loss) were obtained at five knee plates (medial-tibial, lateral-tibial, medial-femoral, lateral-femoral and patellar), and standardized values were analysed. Multivariate logistic regression was used with adjustment for known confounders. Artificial-Neural-Network analysis was conducted by Multi-Layer-Perceptrons (MLPs) including baseline determinants, and baseline (1) and interval changes (2) in cartilage volumes.Results: Larger baseline lateral-femoral cartilage volume was predictive of medial JSL (OR: 1.29 (1.01-1.64)). Greater initial 24th month lateral-femoral cartilage volume-loss (OR: 0.48 (0.27-0.84)) had protective effect on medial JSL during 24-48th months of study. Baseline and interval changes in lateral-femoral cartilage volume, were the most important estimators for medial JSL progression (importance values: 0.191(0.177-0.204), 0.218(0.207-0.228)) in the ANN analyses.Conclusions: Cartilage volumes (both at baseline and their change during the initial 24 months) in the lateral femoral plate were predictive of medial JSL progression.Key Points: • Baseline lateral femoral cartilage volume is directly associated with medial JSL progression. • 24-month lateral femoral cartilage loss is inversely associated with medial JSL progression. • Lateral femoral cartilage volume is most important in association with medial JSL progression. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
