Identifying perfusion deficits on CT perfusion images using temporal similarity perfusion (TSP) mapping
| العنوان: | Identifying perfusion deficits on CT perfusion images using temporal similarity perfusion (TSP) mapping |
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| المؤلفون: | Jill B. De Vis, Jan Willem Dankbaar, Richard C. Reynolds, Wouter Kroon, Reinoud P H Bokkers, Brigitta K Velthuis, Daniel R. Glen, Sunbin Song, Marie Luby, Lawrence L. Latour |
| المساهمون: | Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
| المصدر: | European Radiology, 29(8), 4198. Springer Verlag Eur Radiol European Radiology, 29(8), 4198-4206. SPRINGER |
| بيانات النشر: | SPRINGER, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Computed Tomography Angiography, SEGMENTATION, Perfusion scanning, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, immune system diseases, MEAN TRANSIT-TIME, Medicine, CORE, Tomography, Brain Mapping, Computed Tomography Angiography/methods, Clinical Trials as Topic, Penumbra, Brain, virus diseases, General Medicine, Middle Aged, Multicenter Study, Stroke, Perfusion, Cerebral Arteries/diagnostic imaging, Radiology Nuclear Medicine and imaging, Cerebrovascular Circulation, 030220 oncology & carcinogenesis, Infarct volume, RELIABILITY, Temporal similarity, Female, Radiology, medicine.medical_specialty, endocrine system, PENUMBRA, DCE-MRI, Cerebrovascular Circulation/physiology, Transit time, X-ray computed, Article, PARAMETERS, 03 medical and health sciences, Brain ischemia, Brain Mapping/methods, Brain Ischemia/diagnostic imaging, Journal Article, Humans, Radiology, Nuclear Medicine and imaging, COMPUTED-TOMOGRAPHY, Aged, Retrospective Studies, business.industry, Tomography, X-ray computed, Cerebral Arteries, Brain/diagnostic imaging, Cross-Sectional Studies, VOLUME, business, Nuclear medicine, Kappa, Stroke/diagnostic imaging |
| الوصف: | OBJECTIVES: Deconvolution-derived maps of CT perfusion (CTP) data may be confounded by transit delays. We propose temporal similarity perfusion (TSP) analysis to decrease CTP maps' dependence on transit times and investigate its sensitivity to detect perfusion deficits.METHODS: CTP data of acute stroke patients obtained within 9 h of symptom onset was analyzed using a delay-insensitive singular value decomposition method and with TSP. The TSP method applies an iterative process whereby a pixel's highest Pearson's R value is obtained through comparison of a pixel's time-shifted signal density time-series curve and the average whole brain signal density time-series curve. Our evaluation included a qualitative and quantitative rating of deconvolution maps (MTT, CBV, and TTP), of TSP maps, and of follow-up CT.RESULTS: Sixty-five patients (mean 68 (SD 13) years, 34 male) were included. A perfusion deficit was identified in 90%, 86%, 65%, and 84% of MTT, TTP, CBV, and TSP maps. The agreement of MTT, TTP, and TSP with CT follow-up was comparable but noticeably lower for CBV. CBV had the best relationship with final infarct volume (R2 = 0.77, p CONCLUSIONS: TSP maps are easier to interpret for inexperienced readers. Perfusion deficits detected by TSP are smaller which may suggest less dependence on transit delays although more investigation is required.KEY POINTS: • Temporal similarity perfusion mapping assesses CTP data based on similarities in signal time-curves. • TSP maps are comparable in perfusion deficit detection to deconvolution maps. • TSP maps are easier to interpret for inexperienced readers. |
| وصف الملف: | image/pdf; application/pdf |
| اللغة: | English |
| تدمد: | 0938-7994 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1667c891a597acf299914594a4f65f48Test https://doi.org/10.1007/s00330-018-5896-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1667c891a597acf299914594a4f65f48 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09387994 |
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