Mephenesin dependence: A case series
| العنوان: | Mephenesin dependence: A case series |
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| المؤلفون: | Emmanuel Burin, Samira Djezzar, Florence Vorspan, Robert Garnier, Jean-Pierre Lépine, Dominique Chataigner |
| المصدر: | European Psychiatry. 26:29-29 |
| بيانات النشر: | Cambridge University Press (CUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, Mephenesin, Substance-Related Disorders, MEDLINE, Heroin, medicine, Humans, Pharmacology (medical), Thesaurus (information retrieval), Information retrieval, Series (mathematics), Substance dependence, Muscle Relaxants, Central, business.industry, Alcohol dependence, Middle Aged, Haemolysis, medicine.disease, Substance Withdrawal Syndrome, Psychiatry and Mental health, Anesthesia, Alcohol withdrawal syndrome, Adjunctive treatment, Female, medicine.symptom, business, muscle spasm, medicine.drug |
| الوصف: | IntroductionMephenesin is a central muscle relaxant, acting through a depression of the activity of some neurones in the caudate nucleus. It was proposed as a potential treatment of alcohol withdrawal syndrome in the 50s. This over the counter medicine is now mainly prescribed to treat spasticity or as an adjunctive treatment of painful muscle spasm. We know little about this substance except that side effects are venous thrombosis, haemolysis or cutaneous intolerance. Yet, no case of abuse or dependence has been reported.AimsTo report a series of 5 clinical cases in patients who developed abuse or dependence to mephenesin.MethodsWe performed a systematic search in data bases of both Paris addictovigilance and poison centres from 1999 to 2010. Clinical details were obtained from clinicians when possible. A literature search was also performed to describe mephenesin mechanisms of actions that could be implied.ResultsThree (3) women et 2 men aged 35 to 52 years (m : 43.6) were identified as abusing mephenesin, among which 4 patients had a full DSM IV criteria of dependence. All had a previous history of abuse or substance dependence (alcohol, heroin, codeine, ketamine…).The average mephenesin daily intake was 13 g (9 to 24 g) when the maximum recommended dosage is 3 gr/d. In one case, a withdrawal syndrome was observed (tremor, aggressiveness).ConclusionMephenesin may be abused by patients with previous risk factors, especially a personal history of alcohol dependence. |
| تدمد: | 1778-3585 0924-9338 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9518f992c962edda83c58bc98dd3bdebTest https://doi.org/10.1016/s0924-9338Test(11)71740-0 |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9518f992c962edda83c58bc98dd3bdeb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17783585 09249338 |
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