التفاصيل البيبلوغرافية
| العنوان: |
A Randomised Study Comparing Systemic Transdermal Treatment and Local Application of Glyceryl Trinitrate Ointment in the Management of Chronic Anal Fissure. |
| المؤلفون: |
Colak, Tahsin, Ipek, Turgut, Urkaya, Namik, Kanik, Arzu, Dirlik, Musa |
| المصدر: |
European Journal of Surgery; Dec2002 Supplement 588, Vol. 168 Issue 12, p18-22, 5p |
| مصطلحات موضوعية: |
NITRIC oxide, CLINICAL trials, MEDICAL sciences, TRANSDERMAL medication, DRUG administration, ALTERNATIVE medicine |
| مستخلص: |
Objective: To compare a systemic transdermal therapeutic system with local application of glyceryl trinitrate ointment in the treatment of anal fissure. Design: Perspective, multicentre, randomised trial. Setting: Three teaching hospitals, Turkey. Subjects: 89 outpatients with chronic anal fissure were randomly assigned to be treated with either transdermal (n = 52) or 0.2% glyceryl trinitrate ointment (n = 37). Interventions: The patients were assessed at the sixth and the twelfth week after initial evaluation by physical examination, anoscopy, and anal manometry. Main outcome measures: Changes in the maximal anal resting pressure, healing rate. Results: Anal fissure was completely healed in 38 (73%) and 24 (64%) of the patients after 6 weeks, and 48 (81%) and 27 (79%) of the patients in transdermal group and ointment group, respectively. Maximal anal resting pressure was reduced by 24% and 21% in transdermal and ointment groups, respectively. Conclusion: Systemic transdermal application glyceryl trinitrate gave a satisfactory healing rate, which was comparable to that of local application of ointment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
