The effects of nitric oxide synthase inhibitors on acute necrotising pancreatitis in rats
| العنوان: | The effects of nitric oxide synthase inhibitors on acute necrotising pancreatitis in rats |
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| المؤلفون: | Etem Alhan, Uzer Kucuktulu, Cengiz Erçin |
| المصدر: | European Journal of Surgery. 164:697-702 |
| بيانات النشر: | Oxford University Press (OUP), 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pancreatic disease, Necrosis, Nitric Oxide Synthase Type II, chemistry.chemical_element, Calcium, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, Lactate dehydrogenase, medicine, Animals, Urea, Enzyme Inhibitors, Pancreas, Transaminases, L-Lactate Dehydrogenase, biology, Pancreatitis, Acute Necrotizing, business.industry, medicine.disease, Rats, Surgery, Nitric oxide synthase, NG-Nitroarginine Methyl Ester, Endocrinology, Liver, chemistry, Creatinine, Amylases, biology.protein, Acute pancreatitis, Pancreatitis, Nitric Oxide Synthase, medicine.symptom, business, Isothiuronium |
| الوصف: | Objective: To investigate the effects of the constitutive nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-Name) and the inducible NO synthase inhibitor amino ethyl-isothiourea (AE-ITU) on acute necrotising pancreatitis (ANP) in rats.Design: Laboratory study.Setting: Medical school, Turkey.Main outcome measures: Morbidy, mortality, effects on activities of various enzymes, and histological picture.Results: NO inhibitors increased the mortality (from 8/15, 53%, for ANP plus saline, to 12/15, 80%, for ANP plus L-Name, and 13/15, 87%, for ANP plus AE-ITU and serum amylase activity, but had no effects on serum calcium concentrations, volume of ascites, or degree of pancreatic damage. L-Name caused hypoglycemia, and AE-ITU reduced activites of lactate dehydrogenase and liver transaminases, and concentrations of urea and creatinine.Conclusions: Constitutive NO synthase inhibition worsens the course of ANP, and inducible NO inhibition has beneficial effects on various systems. |
| تدمد: | 1741-9271 1102-4151 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d76341384d791f1d38840193318166Test https://doi.org/10.1080/110241598750005598Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....72d76341384d791f1d38840193318166 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17419271 11024151 |
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