التفاصيل البيبلوغرافية
| العنوان: |
(E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests. |
| المؤلفون: |
Khdhiri, Emna1 (AUTHOR), Mnafgui, Kais2 (AUTHOR), Ghazouani, Lakhdar3 (AUTHOR), Feriani, Anouar3 (AUTHOR), Hajji, Raouf4 (AUTHOR), Bouzanna, Walid5 (AUTHOR), Allouche, Noureddine6 (AUTHOR), Bazureau, Jean-Pierre1,7 (AUTHOR) jean-pierre.bazureau@univ-rennes1.fr, Ammar, Houcine1 (AUTHOR), Abid, Souhir1,8 (AUTHOR) |
| المصدر: |
European Journal of Pharmacology. Aug2020, Vol. 881, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*HEART diseases, *ANTICOAGULANTS, *IN vivo studies, *ANGIOTENSIN converting enzyme, *CARDIAC hypertrophy, *MYOCARDIUM, *ANGIOTENSIN I |
| مستخلص: |
The current study was aimed to assess the protective effect of a new molecule (E)- N' -(1-(3-oxo-3 H -benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c , against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6th and 7th day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC 50 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)- N' -(1-(3-oxo-3 H -benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction. Image 1 • Synthesis of new (E)- N' -[1-(3-oxo-3 H -benzo[f]chromen-2-yl)ethylidene benzohydrazide 1c. • In vitro tests showed potent inhibition of angiotensine I-converting enzyme (ACE). • In vivo assays (on rats), pre-treatment with 1c improved the ECG pattern. • 1c reduced the cardiac dysfunction markers and ameliorated the thrombolytic process. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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