التفاصيل البيبلوغرافية
| العنوان: |
Ca2+ channel activating action of maitotoxin in cultured brainstem neurons |
| المؤلفون: |
Kakizaki, Atsushi1,2, Takahashi, Masami3, Akagi, Hiroyuki4, Tachikawa, Eiichi2, Yamamoto, Toshifumi5, Taira, Eiichi2, Yamakuni, Tohru1, Ohizumi, Yasushi1 ohizumi@mail.pharm.tohoku.ac.jp |
| المصدر: |
European Journal of Pharmacology. May2006, Vol. 536 Issue 3, p223-231. 9p. |
| مصطلحات موضوعية: |
*CALCIUM antagonists, *BRAIN stem, *NEURONS, *PHARMACOLOGY |
| مستخلص: |
Abstract: The actions of maitotoxin were studied using cultured brainstem cells and adrenal chromaffin cells. Maitotoxin induced a profound increase in the Ca2+ influx into cultured brainstem cells after a brief lag period. The maitotoxin-induced Ca2+ influx was suppressed by various voltage-dependent Ca2+ channel blockers such as Co2+, Mn2+, verapamil and diltiazem. Maitotoxin-catecholamine release in brainstem cells initiated to increase after a lag period of about 1min and the increase continued even at 4min after treatment, while in the adrenal chromaffin cells the release started after an about 1-min lag period to attain a maximum within first 2-min and gradually decrease thereafter. These results suggest that maitotoxin acts on Ca2+ channels to increase the Ca2+ influx, accompanied by enhancement of catecholamine release in the brainstem cells with a different temporal profile from that in the adrenal chromaffin cells. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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