التفاصيل البيبلوغرافية
| العنوان: |
Tumor targeting using polyamidoamine dendrimer–cisplatin nanoparticles functionalized with diglycolamic acid and herceptin. |
| المؤلفون: |
Kesavan, Akila1, Ilaiyaraja, P.2, Sofi Beaula, W.1, Veena Kumari, Vuttaradhi3, Sugin Lal, J.4, Arunkumar, C.3, Anjana, G.1, Srinivas, Satish5, Ramesh, Anita6, Rayala, Suresh Kumar3 rayala@iitm.ac.in, Ponraju, D.7 pon@igcar.gov.in, Venkatraman, Ganesh1 ganeshv@sriramachandra.edu.in |
| المصدر: |
European Journal of Pharmaceutics & Biopharmaceutics. Oct2015, Vol. 96, p255-263. 9p. |
| مصطلحات موضوعية: |
*TARGETED drug delivery, *POLYAMIDOAMINE dendrimers, *CISPLATIN, *NANOMEDICINE, *TRASTUZUMAB, *DRUG delivery systems |
| مستخلص: |
Polymer mediated drug delivery system represents a novel promising platform for tumor-targeting with reduced systemic side effects and improved chemotherapeutical efficacy. In this study, we report the preparation and characterization of herceptin targeted, diglycolamic acid (DGA) functionalized polyamidoamine (PAMAM) dendrimer as a potent drug carrier for cisplatin. DGA dendrimers carrying cisplatin demonstrated enhanced anticancer activity when targeted with herceptin. In vitro cell line studies with herceptin-DGA-G4-cisplatin in HER-2 +ve and HER-2 −ve human ovarian cancer cell lines showed that these nanoparticles possessed remarkable features such as lower IC 50 value, improved S-phase arrest, and enhanced apoptosis due to increased cellular uptake and accumulation than the untargeted DGA-G4-cisplatin and free cisplatin. Furthermore, in vivo results in SCID mice bearing SKOV-3 tumor xenografts, herceptin-DGA-G4-cisplatin, appeared to be more effective in inducing tumor regression as compared to free cisplatin. Collectively, these results indicate that herceptin targeted DGA functionalized PAMAM-cisplatin conjugates serve as better anti-tumor agents than individual therapeutic agents. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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