التفاصيل البيبلوغرافية
| العنوان: |
Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor. |
| المؤلفون: |
Vasudevan, N.1, Jachak, Gorakhnath R.1, Reddy, D. Srinivasa1 ds.reddy@ncl.res.in |
| المصدر: |
European Journal of Organic Chemistry. Dec2015, Vol. 2015 Issue 34, p7433-7437. 5p. |
| مصطلحات موضوعية: |
*AMIDES, *INDOLE compounds, *ORGANIC compounds, *ORGANIC synthesis, *ORGANIC chemistry |
| مستخلص: |
A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop-Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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