Penetration of [3H] Tiazofurin Into Guinea Pig Eye by a Saturable Mechanism
| العنوان: | Penetration of [3H] Tiazofurin Into Guinea Pig Eye by a Saturable Mechanism |
|---|---|
| المؤلفون: | Zoran B. Redzic, S. S. Jovanovic, Berislav V. Zlokovic, Ivanka Markovic, Rakic Lm |
| المصدر: | European Journal of Ophthalmology. 5:131-135 |
| بيانات النشر: | SAGE Publications, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Guinea Pigs, Antineoplastic Agents, Aqueous humor, Eye, Aqueous Humor, Guinea pig, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Blood-Retinal Barrier, Ribavirin, medicine, Animals, Perfusion method, Volume of distribution, Chemistry, Biological Transport, General Medicine, Penetration (firestop), Perfusion, Ophthalmology, Biochemistry, 030221 ophthalmology & optometry, Biophysics, 030217 neurology & neurosurgery, Tiazofurin, Half-Life, medicine.drug |
| الوصف: | This study investigated the transport of tiazofurin (2-beta-D-ribofuranosyl thiazole-4-carboxamide) across the blood-aqueous humor barrier, using the vascular perfusion method in the guinea pig. Volume of distribution (Vd) of [3H] tiazofurin increased almost linearly in time, from 4% of its plasma concentration at 3 min to 10% after 12 min of perfusion. Unidirectional transport constant, K(in) was 7.01 +/- 1.06 x 10(-3) ml/min/g. These results indicate that tiazofurin penetrates the aqueous humor to a considerable extent. Addition of unlabelled tiazofurin to the perfusing medium caused a significant decrease in the uptake of [3H] labelled tiazofurin (K(in) = 2.60 +/- 0.91 x 10(-3) ml/min/g). Therefore, penetration of tiazofurin from blood into aqueous humor seems to be a saturable process with a diffusional component that cannot be disregarded. Such findings could be of considerable importance since this molecule is known to affect tissue metabolism. |
| تدمد: | 1724-6016 1120-6721 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00daa0908ca1ae38b3b1a78d96709138Test https://doi.org/10.1177/112067219500500211Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....00daa0908ca1ae38b3b1a78d96709138 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17246016 11206721 |
|---|