Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease
| العنوان: | Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease |
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| المؤلفون: | Tatsuhiro Terada, Joseph Therriault, Min Su Kang, Melissa Savard, Tharick Ali Pascoal, Firoza Lussier, Cecile Tissot, Yi‐Ting Wang, Andrea Benedet, Nina Margherita Poltronetti, Julie Ottoy, Jaime Frenandez Arias, Gleb Bezgin, Takashi Matsudaira, Tomoyasu Bunai, Tomokazu Obi, Hideo Tsukada, Yasuomi Ouchi, Pedro Rosa‐Neto |
| المصدر: | European Journal of Neurology. 29:1324-1334 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Aniline Compounds, Glucose, Neurology, Alzheimer Disease, Fluorodeoxyglucose F18, Positron-Emission Tomography, Brain, Humans, Cognitive Dysfunction, Amyloidosis, Neurology (clinical), Atrophy |
| الوصف: | Abnormal mitochondrial metabolism has been described in the Alzheimer's disease (AD) brain. However, the relationship between AD pathophysiology and key mitochondrial processes remains elusive. The purpose of this study was to investigate whether mitochondrial complex I dysfunction is associated with amyloid aggregation or glucose metabolism and brain atrophy in patients with mild AD using positron emission tomography (PET).Amyloid- and tau-positive symptomatic AD patients with clinical dementia rating 0.5 or 1 (N = 30; mean age ± standard deviation: 71.8 ± 7.6 years) underwent magnetic resonance imaging and PET scans with [[In symptomatic cases, although mitochondrial complex I reduction is linked to a wide range of downstream neurodegenerative processes such as hypometabolism, atrophy, and cognitive decline, a link to amyloid was not observable. The data presented here support [ |
| تدمد: | 1468-1331 1351-5101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab687b78ef6bfcf7f5db204fb515588dTest https://doi.org/10.1111/ene.15246Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ab687b78ef6bfcf7f5db204fb515588d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14681331 13515101 |
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