التفاصيل البيبلوغرافية
| العنوان: |
Morphometric imaging and quantitative susceptibility mapping as complementary tools in the diagnosis of parkinsonisms. |
| المؤلفون: |
Mazzucchi, Sonia, Del Prete, Eleonora, Costagli, Mauro, Frosini, Daniela, Paoli, Davide, Migaleddu, Gianmichele, Cecchi, Paolo, Donatelli, Graziella, Morganti, Riccardo, Siciliano, Gabriele, Cosottini, Mirco, Ceravolo, Roberto |
| المصدر: |
European Journal of Neurology; Oct2022, Vol. 29 Issue 10, p2944-2955, 12p |
| مصطلحات موضوعية: |
MULTIPLE system atrophy, PROGRESSIVE supranuclear palsy, PARKINSON'S disease, MAGNETIC resonance imaging, SUBSTANTIA nigra, MAGNETIC susceptibility |
| مستخلص: |
Background and purpose: In the quest for in vivo diagnostic biomarkers to discriminate Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA, mainly p phenotype), many advanced magnetic resonance imaging (MRI) techniques have been studied. Morphometric indices, such as the Magnetic Resonance Parkinsonism Index (MRPI), demonstrated high diagnostic value in the comparison between PD and PSP. The potential of quantitative susceptibility mapping (QSM) was hypothesized, as increased magnetic susceptibility (Δχ) was reported in the red nucleus (RN) and medial part of the substantia nigra (SNImed) of PSP patients and in the putamen of MSA patients. However, disease‐specific susceptibility values for relevant regions of interest are yet to be identified. The aims of the study were to evaluate the diagnostic potential of a multimodal MRI protocol combining morphometric and QSM imaging in patients with determined parkinsonisms and to explore its value in a population of undetermined cases. Method: Patients with suspected degenerative parkinsonism underwent clinical evaluation, 3 T brain MRI and clinical follow‐up. The MRPI was manually calculated on T1‐weighted images. QSM maps were generated from 3D multi‐echo T2*‐weighted sequences. Results: In determined cases the morphometric evaluation confirmed optimal diagnostic accuracy in the comparison between PD and PSP but failed to discriminate PD from MSA‐p. Significant nigral and extranigral differences were found with QSM. RN Δχ showed excellent diagnostic accuracy in the comparison between PD and PSP and good accuracy in the comparison of PD and MSA‐p. Optimal susceptibility cut‐off values of RN and SNImed were tested in undetermined cases in addition to MRPI. Conclusions: A combined use of morphometric imaging and QSM could improve the diagnostic phase of degenerative parkinsonisms. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder