المؤلفون: Madeira Gírio, Patricia Alexandra, Braun, Florian, Bertoletti, Nicole, Möller, Gabriele, Adamski, Jerzy, Frotscher, Martin, Guragossian, Nathalie, Alexandra, Patrícia, Gírio, Madeira, Le Borgne, Marc, Ettouati, Laurent, Falson, Pierre, Müller, Sebastian, Vollmer, Günther, Heine, Andreas, Klebe, Gerhard, Marchais-Oberwinkler, Sandrine

المساهمون: Microbiologie moléculaire et biochimie structurale / Molecular Microbiology and Structural Biochemistry (MMSB), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Philipps Universität Marburg, Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Helmholtz-Zentrum München (HZM), Saarland University [Saarbrücken], Molécules bioactives et chimie médicinale (B2MC), Université de Lyon-Université de Lyon, Cibles et médicaments de l'infection, de l'immunité et du cancer (IICiMed), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Hôpital d'Instruction des Armées du Val de Grâce, Service de Santé des Armées, Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Chair for Molecular Cell Physiology & Endocrinology, Faculty of Biology, Technical University Dresden, Department of Pharmaceutical Chemistry, Institut de biologie et chimie des protéines [Lyon] (IBCP), Institut für Informatik [Berlin], Freie Universität Berlin, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 155, pp.61-76. ⟨10.1016/j.ejmech.2018.05.029⟩
Eur. J. Med. Chem. 155, 61-76 (2018)

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, 17-Hydroxysteroid Dehydrogenases, Pyridines, Stereochemistry, [SDV.CAN]Life Sciences [q-bio]/Cancer, Dehydrogenase, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Crystallography, X-Ray, 01 natural sciences, Cofactor, Structure-Activity Relationship, 03 medical and health sciences, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Oxidoreductase, Drug Discovery, Humans, Enzyme Inhibitors, Cytotoxicity, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, 17β-hydroxysteroid Dehydrogenase Type 14, Crystallography, Inhibitors, Structure-based Design, General Medicine, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 0104 chemical sciences, 030104 developmental biology, Enzyme, Drug Design, biology.protein, NAD+ kinase, Selectivity, Estrogen receptor alpha

وصف الملف: application/pdf

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https://doi.org/10.1016/j.ejmech.2018.05.029Test

المؤلفون: Olivier Lozach, Laurent Meijer, Aurélien Putey, Guy Fournet, Lionel Perrin, Benoît Joseph

المساهمون: Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Synthèse de Molécules d'Intérêt Thérapeutique (SMITh), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Phophorylation de protéines et Pathologies Humaines (P3H), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Interface Theory Experiment : Mechanism & Modeling (ITEMM)

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 83, pp.617-629. ⟨10.1016/j.ejmech.2014.06.063⟩

مصطلحات موضوعية: Kinase, Inhibitor, Indoles, Stereochemistry, CDK, Chemistry Techniques, Synthetic, Docking, Structure-Activity Relationship, chemistry.chemical_compound, Cyclin-dependent kinase, Catalytic Domain, Drug Discovery, Animals, Humans, Phenyl group, Protein kinase A, Protein Kinase Inhibitors, Pharmacology, Indole test, GSK-3, Cyclin-dependent kinase 1, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, General Medicine, Cyclin-Dependent Kinases, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Molecular Docking Simulation, chemistry, Indole, Docking (molecular), biology.protein, Iodolactonisation, Binding domain

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https://doi.org/10.1016/j.ejmech.2014.06.063Test

المؤلفون: Mohd Afzal, Loïc Toupet, Shazia Parveen, Taibi Ben Hadda, Farukh Arjmand

المساهمون: Faculté des sciences [Oujda], Université Mohammed Premier [Oujda], Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Department of Biotechnology, New Delhi (SchemeNo.BT/PR9205/Med/30/13/2007), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2012, 49, pp.141-50. ⟨10.1016/j.ejmech.2012.01.005⟩
European Journal of Medicinal Chemistry, Elsevier, 2012, 49, pp.141-50. ⟨10.1016/j.ejmech.2012.01.005⟩

مصطلحات موضوعية: Models, Molecular, Intercalation (chemistry), Crystal structure, MESH: Drug Design, Crystallography, X-Ray, 01 natural sciences, chemistry.chemical_compound, Coordination Complexes, MESH: Coordination Complexes, Topo I inhibition activity, Drug Discovery, MESH: Phenanthrolines, MESH: Animals, MESH: DNA Cleavage, MESH: Tin, chemistry.chemical_classification, biology, MESH: DNA, General Medicine, Ligand (biochemistry), [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], MESH: Copper, MESH: Cattle, MESH: Topoisomerase I Inhibitors, MESH: Nucleic Acid Conformation, DNA Topoisomerases, Type I, CuII-SnIV phen complex, CT DNA binding, Molecular docking, Pharmacophore, MESH: Models, Molecular, Phenanthrolines, pBR322 DNA cleavage, Stereochemistry, 010402 general chemistry, Cleavage (embryo), Animals, Humans, DNA Cleavage, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Pharmacology, Nuclease, DNA ligase, MESH: Humans, 010405 organic chemistry, Organic Chemistry, DNA, T4 DNA ligase assay, MESH: Crystallography, X-Ray, 0104 chemical sciences, chemistry, Tin, Drug Design, biology.protein, Nucleic Acid Conformation, Cattle, Topoisomerase I Inhibitors, MESH: DNA Topoisomerases, Type I, Copper

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https://doi.org/10.1016/j.ejmech.2012.01.005Test