المؤلفون: Bing-Bing Chen, Shu-Fen He, Jing Sun, Jia-Xi Chen, Nan-Lian Pan, Xing-Dong Song, Guan-Hai Wang, Jia-Xin Liao

المصدر: European Journal of Medicinal Chemistry. 179:26-37

مصطلحات موضوعية: medicine.medical_treatment, Antineoplastic Agents, Apoptosis, Photodynamic therapy, Mitochondrion, Iridium, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Liver Neoplasms, Experimental, Cell Movement, Drug Discovery, Organometallic Compounds, medicine, Animals, Humans, Cytotoxicity, Guanidine, Cell Proliferation, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, Photosensitizing Agents, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Optical Imaging, Organic Chemistry, Cell Cycle Checkpoints, Hep G2 Cells, General Medicine, Mitochondria, 0104 chemical sciences, Photochemotherapy, Cancer cell, Biophysics, Signal transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e2cfb14448d33cb403044d76e7f960Test
https://doi.org/10.1016/j.ejmech.2019.06.045Test

المؤلفون: Yi-Ying Gu, Miao He, Yang-Jie Wang, Fan Du, Wen-Yao Zhang, Linlin Yang, Yun-Jun Liu, Lan Bai

المصدر: European Journal of Medicinal Chemistry. 178:401-416

مصطلحات موضوعية: Cell cycle checkpoint, Antineoplastic Agents, Apoptosis, Mice, Inbred Strains, Iridium, 01 natural sciences, HeLa, Mice, Structure-Activity Relationship, 03 medical and health sciences, Coordination Complexes, Stomach Neoplasms, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Cell Proliferation, 030304 developmental biology, Pharmacology, Cisplatin, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Cell growth, Chemistry, Cytochrome c, Organic Chemistry, Cell Cycle Checkpoints, Neoplasms, Experimental, General Medicine, biology.organism_classification, Molecular biology, In vitro, 0104 chemical sciences, biology.protein, Drug Screening Assays, Antitumor, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07c00af31a761563e6eed5807f0be4aTest
https://doi.org/10.1016/j.ejmech.2019.06.003Test

المؤلفون: Yong Li, Mingsheng Shen, Peng Bai, Mengshi Hu, Wanhua Zhang, Zihao Zhang, Xue Cui, Minghai Tang, Heying Pei, Lijuan Chen, Zhuang Yang

المصدر: European Journal of Medicinal Chemistry. 178:116-130

مصطلحات موضوعية: Cell cycle checkpoint, Oxadiazole, Antineoplastic Agents, Apoptosis, Histone Deacetylase 1, Mice, SCID, Pharmacology, Hydroxamic Acids, 01 natural sciences, Histones, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Western blot, Mice, Inbred NOD, Tubulin, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Cell Proliferation, 030304 developmental biology, Oxadiazoles, 0303 health sciences, Hydroxamic acid, Molecular Structure, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Organic Chemistry, Acetylation, General Medicine, Burkitt Lymphoma, G1 Phase Cell Cycle Checkpoints, Xenograft Model Antitumor Assays, HDAC1, 0104 chemical sciences, Histone Deacetylase Inhibitors, Molecular Docking Simulation, Female, Histone deacetylase, Drug Screening Assays, Antitumor, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5798e155390708ee66591cb0ab3281bTest
https://doi.org/10.1016/j.ejmech.2019.05.089Test

المؤلفون: Chao-Zai Zhang, Xiaoping Zhou, Wei Sun, Di Liang, Mengnan Jiang, Junli Liu, Chenchen Li, Xiaohong Yang, Shutao Wang, Jiaguo Li, Muxin Zhang

المصدر: European Journal of Medicinal Chemistry. 175:247-268

مصطلحات موضوعية: Cell cycle checkpoint, Protein Conformation, Drug Resistance, Antineoplastic Agents, Cell Cycle Proteins, Triple Negative Breast Neoplasms, Spindle Apparatus, Protein Serine-Threonine Kinases, Structure-Activity Relationship, Chromosome instability, Drug Discovery, medicine, Humans, Protein Kinase Inhibitors, Triple-negative breast cancer, Pharmacology, Chemistry, Kinase, Organic Chemistry, Cancer, General Medicine, Protein-Tyrosine Kinases, medicine.disease, Spindle checkpoint, Centrosome, Drug Design, Cancer cell, Cancer research, M Phase Cell Cycle Checkpoints

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a86595b254e52ab33da7fb9ccdb0bTest
https://doi.org/10.1016/j.ejmech.2019.04.047Test

المؤلفون: Daniel Plano, Juan Antonio Palop, Ignacio Encío, Pablo Garnica, Carmen Sanmartín

المساهمون: Universidad Pública de Navarra. Departamento de Ciencias de la Salud, Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila

المصدر: Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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Academica-e: Repositorio Institucional de la Universidad Pública de Navarra
Universidad Pública de Navarra

مصطلحات موضوعية: Programmed cell death, MAP Kinase Kinase 4, S Phase, Wortmannin, chemistry.chemical_compound, Chloroquine, Cell Line, Tumor, Organoselenium Compounds, Drug Discovery, Autophagy, medicine, Humans, Inducer, Imide, Cancer, Pharmacology, Cyclic imide, Cell Death, Dose-Response Relationship, Drug, Chemistry, Adenylate Kinase, Selenocyanate, Organic Chemistry, AMPK, Cell Cycle Checkpoints, General Medicine, Cytostatic Agents, Diselenide, Enzyme Activation, Cell culture, Cancer research, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3981a81129265c0bd2942bf9ad96039Test
https://doi.org/10.1016/j.ejmech.2019.04.074Test

المؤلفون: Yongchao Zhang, Li Geng, Fan Yang, Haitao Fan, Xushuai Dong, Dong He

المصدر: European Journal of Medicinal Chemistry. 176:61-67

مصطلحات موضوعية: Antineoplastic Agents, Apoptosis, Glioma cell, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Triterpenoid, Ursolic acid, Downregulation and upregulation, Cell Line, Tumor, Glioma, Drug Discovery, Cyclic AMP, medicine, Animals, Humans, Inhibitory effect, 030304 developmental biology, Pharmacology, 0303 health sciences, 010405 organic chemistry, Organic Chemistry, General Medicine, medicine.disease, G1 Phase Cell Cycle Checkpoints, Triterpenes, Rats, 0104 chemical sciences, chemistry, Cancer research, Derivative (chemistry), Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33779ed436e56ee921aacfb593946d3cTest
https://doi.org/10.1016/j.ejmech.2019.04.059Test

المؤلفون: Man Liu, Kuo Hsiung Lee, Xiaoguang Chen, Masuo Goto, Yajun Yang, Li Sheng, Fangfang Lai, Ying Yang, Xiao Liu, Haochao Zhang, Zhiyan Xiao, Yan Li, Liandong Jing

المصدر: European Journal of Medicinal Chemistry. 223:113634

مصطلحات موضوعية: Male, Pyridines, Cancer therapy, Mice, Nude, Antineoplastic Agents, 01 natural sciences, Flow cytometry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Pyridine, medicine, Animals, Humans, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, Cyclin, Pharmacology, Mice, Inbred BALB C, 0303 health sciences, Ligand efficiency, Molecular Structure, medicine.diagnostic_test, 010405 organic chemistry, Kinase, Organic Chemistry, General Medicine, Cyclin-Dependent Kinase 8, G1 Phase Cell Cycle Checkpoints, Xenograft Model Antitumor Assays, 0104 chemical sciences, G2 Phase Cell Cycle Checkpoints, Molecular Docking Simulation, chemistry, Biochemistry, Drug Design, Cyclin-dependent kinase 8, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b678c29df1340960fda2ceb5a6661113Test
https://doi.org/10.1016/j.ejmech.2021.113634Test

المؤلفون: Yang Song, Juan Zhang, Cheng Yang, Hongli Pan, Mingming Wei, Benlong Li, Jingjing Wang, Jiefu Wang, Guang Yang, Zhen Zhang, Rui Zhao, Yujiao Wei, Chuangke Chong, Maodun Xie, Li Yu

المصدر: European journal of medicinal chemistry. 206

مصطلحات موضوعية: STAT3 Transcription Factor, Cell cycle checkpoint, Antineoplastic Agents, Breast Neoplasms, Chemistry Techniques, Synthetic, 01 natural sciences, Stat3 Signaling Pathway, Histones, 03 medical and health sciences, Breast cancer, Tubulin, Cell Line, Tumor, Drug Discovery, medicine, Humans, 030304 developmental biology, Pharmacology, 0303 health sciences, Tumor microenvironment, biology, Dose-Response Relationship, Drug, 010405 organic chemistry, Chemistry, Organic Chemistry, Acetylation, General Medicine, medicine.disease, Flavones, G1 Phase Cell Cycle Checkpoints, 0104 chemical sciences, Histone Deacetylase Inhibitors, Histone, Apoptosis, Drug Design, S Phase Cell Cycle Checkpoints, Cancer research, biology.protein, Histone deacetylase, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b5476265438e4b8ed5a26fbf8cb27Test
https://pubmed.ncbi.nlm.nih.gov/32823005Test

المؤلفون: Jie liu, Zhong-Zhen Zhou, Jiangping Xu, Haitao Wang, Xiao-Fang Li, Wan Ye, Wen-Ya Wang

المصدر: European journal of medicinal chemistry. 224

مصطلحات موضوعية: Cell cycle checkpoint, Lung Neoplasms, Apoptosis, chemistry.chemical_compound, Structure-Activity Relationship, Microtubule, Tubulin, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, Cyclin B1, Oxazoles, Oxazole, Cell Proliferation, Pharmacology, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, General Medicine, Cell Cycle Checkpoints, Glioma, Tubulin Modulators, Cyclic Nucleotide Phosphodiesterases, Type 4, Mechanism of action, Cell culture, Cancer research, biology.protein, Phosphodiesterase 4 Inhibitors, medicine.symptom, Drug Screening Assays, Antitumor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd30b415c0c8182cd60a6cf90810ea2aTest
https://pubmed.ncbi.nlm.nih.gov/34311158Test

المؤلفون: Ya-Jie Tang, Long He, Tian-Le Xiang, Wei Zhao

المصدر: European Journal of Medicinal Chemistry. 170:73-86

مصطلحات موضوعية: Male, Stereochemistry, Mice, Nude, Drug design, Antineoplastic Agents, 01 natural sciences, Tubulin binding, 03 medical and health sciences, chemistry.chemical_compound, Tubulin, Drug Discovery, medicine, Animals, Humans, Colchicine, Potency, Binding site, Podophyllotoxin, 030304 developmental biology, Pharmacology, Indole test, Mice, Inbred BALB C, 0303 health sciences, Binding Sites, biology, 010405 organic chemistry, Organic Chemistry, Cell Cycle Checkpoints, General Medicine, Tubulin Modulators, 0104 chemical sciences, Molecular Docking Simulation, chemistry, Drug Design, biology.protein, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252ac8a3fbecbcb971725837c963e77eTest
https://doi.org/10.1016/j.ejmech.2019.03.006Test