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1
المؤلفون: Yi-Ying Gu, Miao He, Yang-Jie Wang, Fan Du, Wen-Yao Zhang, Linlin Yang, Yun-Jun Liu, Lan Bai
المصدر: European Journal of Medicinal Chemistry. 178:401-416
مصطلحات موضوعية: Cell cycle checkpoint, Antineoplastic Agents, Apoptosis, Mice, Inbred Strains, Iridium, 01 natural sciences, HeLa, Mice, Structure-Activity Relationship, 03 medical and health sciences, Coordination Complexes, Stomach Neoplasms, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Cell Proliferation, 030304 developmental biology, Pharmacology, Cisplatin, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Cell growth, Chemistry, Cytochrome c, Organic Chemistry, Cell Cycle Checkpoints, Neoplasms, Experimental, General Medicine, biology.organism_classification, Molecular biology, In vitro, 0104 chemical sciences, biology.protein, Drug Screening Assays, Antitumor, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07c00af31a761563e6eed5807f0be4aTest
https://doi.org/10.1016/j.ejmech.2019.06.003Test -
2
المؤلفون: Mohamed Reda Zahi, Sadeeq Ullah, Chunhui Cheng, Qipeng Yuan, Jie He, Fan Yun
المصدر: European Journal of Medicinal Chemistry. 176:195-207
مصطلحات موضوعية: Antineoplastic Agents, Apoptosis, Sulfides, 01 natural sciences, HeLa, Mice, 03 medical and health sciences, Cell Movement, Cell Line, Tumor, Drug Discovery, Animals, Humans, Cytotoxicity, Cell Proliferation, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Histone deacetylase 2, Organic Chemistry, General Medicine, Cell cycle, biology.organism_classification, Xenograft Model Antitumor Assays, 0104 chemical sciences, G2 Phase Cell Cycle Checkpoints, Histone Deacetylase Inhibitors, Molecular Docking Simulation, Cell culture, Drug Design, Benzamides, Cancer cell, NIH 3T3 Cells, Cancer research, Histone deacetylase, Drug Screening Assays, Antitumor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf331b26c9ebb28e4bc2aef706f05c98Test
https://doi.org/10.1016/j.ejmech.2019.05.007Test -
3
المؤلفون: Jun Sun, Kai Bao, Weige Zhang, Qi Guan, Min'an Zhai, Long Wang, Yingliang Wu, Jianan Du, Daiying Zuo, Meiqi Gao, Shiyuan Liu
المصدر: European Journal of Medicinal Chemistry. 168:426-435
مصطلحات موضوعية: Models, Molecular, Molecular model, Pyridines, Stereochemistry, Antineoplastic Agents, 01 natural sciences, Polymerization, HeLa, Structure-Activity Relationship, 03 medical and health sciences, Tubulin, Cell Line, Tumor, Drug Discovery, Humans, MTT assay, Cytoskeleton, Density Functional Theory, Cell Proliferation, 030304 developmental biology, Pharmacology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Carbonyl reduction, Rational design, Cell Cycle Checkpoints, General Medicine, biology.organism_classification, 0104 chemical sciences, Drug Design, biology.protein, Pyrazoles, Drug Screening Assays, Antitumor, Linker
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec91cca6e8e0b8a8fc51e21695fa434Test
https://doi.org/10.1016/j.ejmech.2018.12.053Test -
4
المؤلفون: Jialei Song, Yanmei Li, Xin Lin, Dongsong Tian, Wei Gu, Yan-Hui Fu, Min Wen, Lie-Jun Huang, Chun-Mao Yuan, Yaacov Ben-David, Xiao-Jiang Hao, Ya-Nan Li
المصدر: European Journal of Medicinal Chemistry. 162:765-780
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Cell cycle checkpoint, Cell, Apoptosis, Resting Phase, Cell Cycle, 01 natural sciences, HeLa, Benzophenones, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, medicine, Humans, Cyclin D1, Polycyclic Compounds, MTT assay, Cytotoxicity, bcl-2-Associated X Protein, 030304 developmental biology, Pharmacology, 0303 health sciences, Leukemia, Molecular Structure, biology, Cytotoxins, 010405 organic chemistry, Chemistry, Organic Chemistry, Cell Cycle Checkpoints, General Medicine, Cell cycle, biology.organism_classification, Molecular biology, 0104 chemical sciences, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Cell culture
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccfe292e71a43cdaea60b3046381babTest
https://doi.org/10.1016/j.ejmech.2018.11.046Test -
5
المؤلفون: Ya-Liang Zhang, Ya-Juan Qin, Hai-Liang Zhu, Fan Jing, Ma Xiang, Kun Chen
المصدر: European Journal of Medicinal Chemistry. 156:722-737
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Indoles, Stereochemistry, Cell, Mice, Nude, Mitosis, Uterine Cervical Neoplasms, Antineoplastic Agents, Apoptosis, Pyrazoline, HeLa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, Moiety, Pharmacology, Indole test, biology, Organic Chemistry, Cell Cycle Checkpoints, General Medicine, biology.organism_classification, Tubulin Modulators, HEK293 Cells, 030104 developmental biology, medicine.anatomical_structure, Tubulin, chemistry, Docking (molecular), Drug Design, 030220 oncology & carcinogenesis, biology.protein, Pyrazoles, Female, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe569fa6785c1b18490ea70de50ca3cTest
https://doi.org/10.1016/j.ejmech.2018.07.044Test -
6
المؤلفون: Dan Li, Huan Tang, Suhong Fu, Lijuan Chen, Aihua Peng, Li Wan, Haoyu Ye, Yongguang Zhang, Minghai Tang, Zhuowei Liu, Linlin Xue, Kai Chen
المصدر: European Journal of Medicinal Chemistry. 156:190-205
مصطلحات موضوعية: 0301 basic medicine, Honokiol, Lung Neoplasms, Cyclin E, Cell cycle checkpoint, Mice, Nude, Apoptosis, Pharmacology, Lignans, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cyclin D1, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, Human Umbilical Vein Endothelial Cells, Animals, Humans, Cell Proliferation, Mice, Inbred BALB C, biology, Biphenyl Compounds, Organic Chemistry, Cyclin-dependent kinase 2, Cell Cycle Checkpoints, General Medicine, biology.organism_classification, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Magnolol, Magnolia officinalis, 030104 developmental biology, chemistry, Magnolia, 030220 oncology & carcinogenesis, biology.protein, Female
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65caafb9bbfb6fdbe23e5c0e4abd82fTest
https://doi.org/10.1016/j.ejmech.2018.06.048Test -
7
المؤلفون: Yunhua Zheng, Lun Wang, Suhong Fu, Wei Zheng, Jianhong Yang, Xu Ma, Yun-Zi Luo, Minghai Tang, Lijuan Chen, Linlin Xue, Aihua Peng, Qi-Yuan Zhao, Heying Pei, Dexin Deng, Min Zhao, Ling Liu, Haoyu Ye, Kongjun Liu
المصدر: European journal of medicinal chemistry. 209
مصطلحات موضوعية: Honokiol, Lung Neoplasms, Apoptosis, Pharmacology, 01 natural sciences, Lignans, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Oral administration, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Autophagy, Animals, Humans, Lung cancer, 030304 developmental biology, 0303 health sciences, Mice, Inbred BALB C, biology, 010405 organic chemistry, Chemistry, Plant Extracts, Organic Chemistry, Biphenyl Compounds, General Medicine, Cell Cycle Checkpoints, biology.organism_classification, medicine.disease, Antineoplastic Agents, Phytogenic, Magnolol, 0104 chemical sciences, Magnolia officinalis, Solubility, Magnolia, Cancer cell, Female, Drug Screening Assays, Antitumor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2e7b306b668ae4d2248a673345d43Test
https://pubmed.ncbi.nlm.nih.gov/33069436Test -
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المؤلفون: Wen-Hua Chen, Cheng-Jun Wu, Hu Jinhui, Zimai Zeng, Jia-Qiang Wu, Suyun Pu, Yunfei Hu, Yuying Lin
المصدر: European Journal of Medicinal Chemistry. 223:113629
مصطلحات موضوعية: Indoles, Cell cycle checkpoint, Pyridines, Stereochemistry, Substituent, Antineoplastic Agents, Apoptosis, 01 natural sciences, Microtubule polymerization, HeLa, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Movement, Tubulin, Microtubule, Cell Line, Tumor, Drug Discovery, Pyridine, Animals, Humans, Cell Proliferation, 030304 developmental biology, Pharmacology, Indole test, 0303 health sciences, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, General Medicine, Triazoles, biology.organism_classification, Tubulin Modulators, Rats, 0104 chemical sciences, G2 Phase Cell Cycle Checkpoints, Molecular Docking Simulation, chemistry, Polymerization, Drug Design, Cattle, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bd883e5ece9d16d0ef3bdfc315b6f8Test
https://doi.org/10.1016/j.ejmech.2021.113629Test -
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المؤلفون: Ala-Eddin Al Moustafa, Dana Elkhalifa, Mohammed H. Qusa, Feras Q. Alali, Farhan S. Cyprian, Abu Bakar Siddique, Ashraf A. Khalil, Khalid A. El Sayed
المصدر: European journal of medicinal chemistry. 187
مصطلحات موضوعية: Models, Molecular, Chalcone, Cell cycle checkpoint, Cell Survival, Nitrogen, Mice, Nude, Cancer progression, Apoptosis, Triple Negative Breast Neoplasms, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 1 (3 chlorophenyl) 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 (3 methoxyphenyl) 3 [4 (piperidin 1 yl)phenyl]prop 2 en 1 one, 1 (3 methoxyphenyl) 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 (benzo[d][1,3]dioxol 5 yl) 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylsulfonyl)phenyl] 3 (4 morpholinophenyl)prop 2 en 1 one, 1 [4 (methylsulfonyl)phenyl] 3 [4 (piperidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylsulfonyl)phenyl] 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylthio)phenyl) 3 [4 (piperidin 1 yl)phenyl]prop 2 en 1 one, 1 [4 (methylthio)phenyl] 3 (4 morpholinophenyl)prop 2 en 1 one, 1 [4 (methylthio)phenyl] 3 [4 (pyrrolidin 1 yl)phenyl]prop 2 en 1 one, 3 (4 morpholinophenyl) 1 [4 (piperazin 1 yl) phenyl)prop 2 en 1 one, 3 [4 [bis(2 chloroethyl)amino]phenyl] 1 (2 methoxyphenyl)prop 2 en 1 one, 3 [4 [bis(2 chloroethyl)amino]phenyl] 1 [4 (methylsulfonyl)phenyl]prop 2 en 1 one, antineoplastic agent, chalcone derivative, chlormethine, colchicine, estrogen, morpholine, P cadherin, paclitaxel, piperidine derivative, protein Bax, protein bcl 2, pyrrolidine derivative, unclassified drug, uvomorulin, vasculotropin receptor 2, [3 [4 [bis(2 chloroethyl)amino]phenyl] 1 (3 methoxyphenyl)prop 2 en 1 one], chalcone, nitrogen, angiogenesis, animal cell, animal experiment, animal model, antineoplastic activity, antiproliferative activity, apoptosis, Article, cancer inhibition, cell invasion, cell migration, chorioallantois, clinical effectiveness, clinical evaluation, colony formation, comparative study, concentration response, controlled study, cytotoxicity, down regulation, drug design, drug efficacy, drug identification, drug synthesis, epithelial mesenchymal transition, G2 phase cell cycle checkpoint, human, human cell, IC50, in vivo study, MCF-7 cell line, MDA-MB-231 cell line, MDA-MB-468 cell line, mouse, nonhuman, triple negative breast cancer, tumor xenograft, upregulation, animal, cell cycle checkpoint, cell proliferation, cell survival, chemical structure, chemistry, dose response, drug effect, drug screening, experimental mammary neoplasm, female, molecular model, nude mouse, pathology, structure activity relation, synthesis, tumor cell culture, Animals, Cell Cycle Checkpoints, Cell Proliferation, Dose-Response Relationship, Drug, Drug Design, Drug Screening Assays, Antitumor, Female, Humans, Mammary Neoplasms, Experimental, Molecular Structure, Tumor Cells, Cultured, Nude mouse, Drug Discovery, Epithelial–mesenchymal transition, Triple-negative breast cancer, 030304 developmental biology, Pharmacology, E-cadherin/catenin complex and its signaling pathways, 0303 health sciences, biology, 010405 organic chemistry, Oral cancer, Organic Chemistry, Emt, General Medicine, biology.organism_classification, Nitrogen mustard, 0104 chemical sciences, Cell culture, Cancer research
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877db4dbb7ab790d9a59c4c276405d6dTest
https://pubmed.ncbi.nlm.nih.gov/31838326Test -
10
المؤلفون: Xinyi Wang, Feihong Chen, Shaohua Gou, Shixian Hua
المصدر: European journal of medicinal chemistry. 189
مصطلحات موضوعية: Male, T-Lymphocytes, Mice, Nude, Antineoplastic Agents, Apoptosis, medicine.disease_cause, 01 natural sciences, HeLa, 03 medical and health sciences, chemistry.chemical_compound, Cell Movement, Neoplasms, Drug Discovery, medicine, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Kynurenine, 030304 developmental biology, Cell Proliferation, Pharmacology, Combretastatin, 0303 health sciences, Mice, Inbred BALB C, biology, 010405 organic chemistry, Organic Chemistry, Cancer, Cell migration, General Medicine, biology.organism_classification, medicine.disease, Xenograft Model Antitumor Assays, Tubulin Modulators, 0104 chemical sciences, G2 Phase Cell Cycle Checkpoints, chemistry, Drug Design, Cancer research, Drug Screening Assays, Antitumor, Reactive Oxygen Species, Oxidative stress, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c5c3fab6eaa00cfefb892c7c39f558Test
https://pubmed.ncbi.nlm.nih.gov/31954880Test