Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis
| العنوان: | Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis |
|---|---|
| المؤلفون: | Kelly C. Lear-Kaul, Britta Siegmund, Raffaella Faggioni, Giamila Fantuzzi |
| المصدر: | European Journal of Immunology. 32:552-560 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Hepatitis, education.field_of_study, medicine.medical_specialty, Leptin Deficiency, Leptin, Lymphocyte, Immunology, Population, Biology, medicine.disease, Gold thioglucose, medicine.anatomical_structure, Endocrinology, Internal medicine, medicine, Immunology and Allergy, Tumor necrosis factor alpha, Interferon gamma, education, medicine.drug |
| الوصف: | Leptin-deficient ob/ob mice are protected from Con A-induced hepatitis. However, it is unclear whether leptin deficiency or obesity itself is responsible for this protection. To address this question, wild-type (WT) obese mice with high serum leptin levels were generated by injection of gold thioglucose (WT GTG). Both Con A-injected WT and WT GTG mice developed hepatitis, whereas no hepatic damage was observed in ob/ob mice. Moreover, TNF-alpha and IFN-gamma levels as well as expression of the activation marker CD69 were elevated in liver mononuclear cells of WT and WT GTG mice, but not in ob/ob mice following administration of Con A. The liver of WT and WT GTG mice had the same percentage of NK T cells, a lymphocyte population involved in Con A-induced hepatitis. This population decreased equally in both WT and WT GTG mice after Con A injection. In contrast, the liver of ob/ob mice contained 50% less NK T cells compared to WT and WT GTG mice. Furthermore, no decrease in NK T cells was observed in Con A-injected ob/ob mice. We conclude that leptin-deficiency, not obesity, is responsible for protection from Con A-induced hepatitis. |
| تدمد: | 1521-4141 0014-2980 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a36e33dc4583045446d830b842155a57Test https://doi.org/10.1002/1521-4141Test(200202)32:2<552::aid-immu552>3.0.co;2-h |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........a36e33dc4583045446d830b842155a57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214141 00142980 |
|---|