Trial characteristics associated with under‐enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review
| العنوان: | Trial characteristics associated with under‐enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review |
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| المؤلفون: | Yousif Eliya, Kristen Sullivan, Sera Whitelaw, Harriette G.C. Van Spall, Mohammad Alruwayeh, Roxana Mehran, Clyde W. Yancy, Lehana Thabane, Mamas A. Mamas |
| المصدر: | European Journal of Heart Failure. 23:15-24 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Asia, MEDLINE, 030204 cardiovascular system & hematology, Logistic regression, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, Randomized Controlled Trials as Topic, Heart Failure, Ejection fraction, business.industry, Odds ratio, Middle Aged, medicine.disease, Confidence interval, 3. Good health, Europe, Heart failure, North America, Ambulatory, Female, Cardiology and Cardiovascular Medicine, business |
| الوصف: | AIMS To evaluate temporal trends in the enrolment of females in randomized controlled trials (RCTs) of heart failure with reduced ejection fraction (HFrEF) published in high-impact journals, and assess RCT characteristics associated with under-enrolment. METHODS AND RESULTS We searched MEDLINE, EMBASE and CINAHL for studies published from January 2000 to May 2019 in journals with impact factor ≥10. We included RCTs that recruited adults with HFrEF. We used a 20% threshold below the sex distribution of HFrEF to define under-enrolment. We used multivariable logistic regression to assess trial characteristics independently associated with under-enrolment. We included 317 RCTs. Among the 183 097 participants, mean (standard deviation) age was 63.0 (7.0) years and 25.5% were female. Females were under-enrolled in 71.6% [95% confidence interval (CI) 66.6-76.6%] of the RCTs; enrolment did not increase significantly between 2000-2019. Sex-related eligibility criteria [odds ratio (OR) 2.05, 95% CI 1.01-4.16; P = 0.046]; recruitment in ambulatory settings (OR 2.56, 95% CI 1.37-4.81; P = 0.003); trial coordination in North America (OR 4.44, 95% CI 1.09-18.07; P = 0.037), Europe (OR 6.79, 95% CI 1.63-27.39; P = 0.018) and Asia (OR 9.33, 95% CI 1.40-12.40; P = 0.033); drug (OR 1.76, 95% CI 1.96-7.36; P |
| تدمد: | 1879-0844 1388-9842 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96495c7354b97cef101138b852eb8e4Test https://doi.org/10.1002/ejhf.2034Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a96495c7354b97cef101138b852eb8e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790844 13889842 |
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