Hepatitis C virus-microelimination program and patient trajectories after hepatitis C virus cure in an outpatient HIV clinical unit
| العنوان: | Hepatitis C virus-microelimination program and patient trajectories after hepatitis C virus cure in an outpatient HIV clinical unit |
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| المؤلفون: | Caroline Lions, Emmanuelle Ressiot, Olivia Zaegel-Faucher, Alena Ivanova, Marie-Ange Pieve, Véronique Obry-Roguet, Perrine Geneau de Lamarliere, Catherine Tamalet, Patrizia Carrieri, Anne-Suzel Ritleng, Caroline Debreux, Sylvie Bregigeon, Isabelle Poizot-Martin, Caroline Solas, Hélène Laroche |
| المساهمون: | Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Bidaut, Ghislain, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU) |
| المصدر: | European Journal of Gastroenterology & Hepatology European Journal of Gastroenterology & Hepatology, 2020, pp.1. ⟨10.1097/MEG.0000000000001640⟩ European Journal of Gastroenterology and Hepatology European Journal of Gastroenterology and Hepatology, Lippincott, Williams & Wilkins, 2020, pp.1. ⟨10.1097/MEG.0000000000001640⟩ |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Hepatitis C virus, [SDV]Life Sciences [q-bio], MEDLINE, HIV Infections, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Hepacivirus, medicine.disease_cause, Antiviral Agents, Serology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Outpatients, medicine, Humans, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Hepatology, business.industry, Coinfection, Gastroenterology, virus diseases, Guideline, Hepatitis C, Hepatitis C, Chronic, medicine.disease, Mental health, digestive system diseases, 3. Good health, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, Cohort study |
| الوصف: | Objective Treatment recommendations for hepatitis C now make no distinction between HIV/HCV-coinfected and HCV-monoinfected patients. The largest challenge remained lack of effective models to eliminate HCV in people living with HIV. We report the results of a microelimination program evaluating the possibility of eradicating HCV in an HIV-outpatient clinical unit within 12 months. Methods This HCV-microelimination program began in February 2016 in an unit following approximately 1000 HIV-infected patients and combined screening and therapeutic components according to the French guideline. A nested cohort study evaluating the impact of HCV cure on different health outcomes was conducted through self-administered questionnaires and using generalized mixed models. Results Among 601 patients eligible for HCV serological testing, 445 were evaluated, and two HCV acute infections were diagnosed. Among the 151 patients eligible for HCV RNA quantification, 119 were evaluated, and one reinfection with HCV was diagnosed. Among the 110 patients eligible for direct-acting antiviral treatment, 51 (46.4%) initiated treatment within the 12 months program, and 35 (31.8%) after. Sustained virologic response (SVR) rate was 96.1%, and two treatments failed. At least one self-reported symptom was declared by 72.5% (n = 29) of patients. Positive impact of HCV cure was observed on various markers of physical and mental health as well as on health habits. Conclusion Our program should be considered as a proof of concept, which confirmed the feasibility of a HCV-microelimination program at the scale of an HIV clinical unit. However, 12 months were not sufficient to achieve our objective despite the specific organization. |
| وصف الملف: | application/pdf |
| تدمد: | 1473-5687 0954-691X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b3377ade93a0c97f47efd70f0c3736Test https://pubmed.ncbi.nlm.nih.gov/31851097Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77b3377ade93a0c97f47efd70f0c3736 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14735687 0954691X |
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