Thyroid examination in highly radiation-exposed workers after the Chernobyl accident
| العنوان: | Thyroid examination in highly radiation-exposed workers after the Chernobyl accident |
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| المؤلفون: | Silke Rosinger, Johannes W. Dietrich, Marianna Steinert, Ralf U. Peter, Theodor M. Fliedner, Gerald Wagemaker, Melanie Weiss, Bernhard O. Boehm, David Belyi |
| المساهمون: | Hematology |
| المصدر: | European Journal of Endocrinology, 160, 625-630. Bioscientifica Ltd |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Thyroid Hormones, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Context (language use), Thyroid Function Tests, Chernobyl Nuclear Accident, Thyroid function tests, Endocrinology, Internal medicine, Occupational Exposure, Radioactive contamination, Medicine, Humans, Radiation Injuries, Thyroid cancer, Physical Examination, Aged, Autoantibodies, Ultrasonography, medicine.diagnostic_test, business.industry, Thyroid, General Medicine, Middle Aged, medicine.disease, Beta Particles, medicine.anatomical_structure, Cross-Sectional Studies, Gamma Rays, Cohort, Acute Disease, Thyroid Stimulating Immunoglobulin, business, Follow-Up Studies, Iodine |
| الوصف: | ContextRadioactive contamination from the Chernobyl nuclear accident that happened on the morning of 26th April 1986 had a major impact on thyroid health in the Belarus region.ObjectiveObservational study of a cohort of 99 adults, most strongly exposed to ionizing radioactivity.Design, setting and patientsObservational study performed between 1998 and 2000. The cohort comprised 99 workers (92 male) of the Chernobyl nuclear power plant. Examination including physical examination, ultrasonography of the thyroid gland and measurement of serum free thyroxin (fT4), free triiodothyronine (fT3) and TSH. Anti-thyroperoxidase (anti-TPO), antithyroglobulin (anti-Tg) antibodies and thyroid stimulating immunoglobulin were also determined.Main outcome measuresThe impact of exposure to high-dose radiation, including radioactive iodine, on the thyroid gland was examined.ResultsLevels of fT4in all probands were within the normal World Health Organization-defined range. Elevated levels of fT3were found in two workers (2%), high titres of anti-TPO and anti-Tg antibodies were present in four subjects (4%). Mild hypothyroidism was present in one patient. Enlargement of the thyroid gland was observed in 17 workers (17%). There was no evidence of clinically overt thyroid cancer.ConclusionsThe Chernobyl accident showed surprisingly little impact on the thyroid in a cohort of workers strongly exposed to radiation. Our data suggest an age-dependent heterogeneity in response to the short-lived radioiodine isotopes and favours long-term follow-up analysis. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99fdfc6585dc26cb43dd98ae2effce2Test https://pubmed.ncbi.nlm.nih.gov/19147598Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c99fdfc6585dc26cb43dd98ae2effce2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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