The Effect of Myricetin on Pharmacokinetics of Atomoxetine and its Metabolite 4-Hydroxyatomoxetine In Vivo and In Vitro
| العنوان: | The Effect of Myricetin on Pharmacokinetics of Atomoxetine and its Metabolite 4-Hydroxyatomoxetine In Vivo and In Vitro |
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| المؤلفون: | Wen-He Pan, Bing-Qing Liang, Quan Zhou, Ling-jing Yuan, Guo-Xin Hu, Tian Lan, Xiao-Xia Hu |
| المصدر: | European Journal of Drug Metabolism and Pharmacokinetics. 42:261-268 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Metabolite, Pharmacology, Atomoxetine Hydrochloride, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenols, Pharmacokinetics, In vivo, medicine, Animals, Humans, Drug Interactions, Pharmacology (medical), IC50, Flavonoids, Adrenergic Uptake Inhibitors, Dose-Response Relationship, Drug, Propylamines, Atomoxetine, Rats, chemistry, Area Under Curve, Microsomes, Liver, Microsome, Myricetin, 030217 neurology & neurosurgery, medicine.drug, Atomoxetine hydrochloride |
| الوصف: | Atomoxetine is the first non-stimulant drug to be approved for the treatment of ADHD, while the effect of myricetin on the pharmacokinetic of atomoxetine in rats or human is still unknown. The present work was to study the impact of myricetin on the metabolism of atomoxetine both in vivo and in vitro. Twenty healthy male Sprague–Dawley rats were randomly divided into four groups: A (control group), B (100 mg/kg myricetin), C (50 mg/kg myricetin), and D (25 mg/kg myricetin). A single dose of atomoxetine (10 mg/kg) was administrated half an hour later. In addition, human and rat liver microsomes were performed to determine the effect of myricetin on the metabolism of atomoxetine in vitro. Group B, C, D all increased the C max and AUC of atomoxetine, but decreased the C max and AUC of 4-hydroxyatomoxetine. Moreover, myricetin showed inhibitory effect on human and rat microsomes, the IC50 of myricetin was 8.651 and 35.45 µmol/L, respectively. Our study showed that myricetin could significantly inhibit the formation of atomoxetine metabolite both in vivo and in vitro. It is recommended that the effect of myricetin on the metabolism of atomoxetine should be noted and atomoxetine plasma concentration should be monitored. |
| تدمد: | 2107-0180 0378-7966 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ecdaff41d3a0b8f11d4bb1d32d61e4Test https://doi.org/10.1007/s13318-016-0347-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....45ecdaff41d3a0b8f11d4bb1d32d61e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21070180 03787966 |
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