نتائج البحث

1

Randomized, placebo-controlled trial of orally administered vitamin K1 for warfarin-associated coagulopathy in Chinese patients with mechanical heart valves

المؤلفون: Mei Li, Li Dong, Yijun Dong, Heng Zhang, Xuelian Ao

المصدر: European Journal of Clinical Pharmacology. 77:1333-1339

مصطلحات موضوعية: Adult, Male, Vitamin, China, medicine.drug_class, Placebo-controlled study, Hemorrhage, Placebo, 030226 pharmacology & pharmacy, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, medicine, Coagulopathy, Humans, Warfarin resistance, Pharmacology (medical), International Normalized Ratio, Prospective Studies, cardiovascular diseases, 030212 general & internal medicine, Pharmacology, Dose-Response Relationship, Drug, business.industry, Anticoagulant, Warfarin, Anticoagulants, Vitamin K 1, General Medicine, Blood Coagulation Disorders, Middle Aged, medicine.disease, Antifibrinolytic Agents, chemistry, Heart Valve Prosthesis, Anesthesia, Female, medicine.symptom, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ecc0e861c57a1ae705e27e360c90b2Test
https://doi.org/10.1007/s00228-021-03127-8Test

2

Siponimod pharmacokinetics, safety, and tolerability in combination with the potent CYP3A4 inhibitor itraconazole in healthy subjects with different CYP2C9 genotypes

المؤلفون: Anne Gardin, Swati Dumitras, Srikanth Neelakantham, Felix Huth, Andrea Feller, Kasra Shakeri-Nejad

المصدر: European Journal of Clinical Pharmacology. 75:1565-1574

مصطلحات موضوعية: Adult, Male, Sphingosine 1 Phosphate Receptor Modulators, medicine.medical_specialty, Adolescent, Genotype, Itraconazole, Cmax, 030226 pharmacology & pharmacy, Gastroenterology, Electrocardiography, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, Benzyl Compounds, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Pharmacology (medical), Lymphocyte Count, 030212 general & internal medicine, Adverse effect, CYP2C9, Cytochrome P-450 CYP2C9, Pharmacology, business.industry, General Medicine, Middle Aged, Healthy Volunteers, Siponimod, Tolerability, chemistry, Area Under Curve, Cohort, Azetidines, Cytochrome P-450 CYP3A Inhibitors, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11214a189361ffc50b5764ae3d7ce871Test
https://doi.org/10.1007/s00228-019-02729-7Test

3

A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents

المؤلفون: Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder

المصدر: European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-yTest, https://doi.org/10.1007/s00228-019-02697-yTest

مصطلحات موضوعية: Male, Simvastatin, Metabolite, Pharmacology, 030226 pharmacology & pharmacy, chemistry.chemical_compound, 0302 clinical medicine, population pharmacokinetics, polycyclic compounds, Metabolites, Cytochrome P-450 CYP3A, Pharmacology (medical), 030212 general & internal medicine, Population pharmacokinetics, Child, metabolites, education.field_of_study, biology, Liver-Specific Organic Anion Transporter 1, General Medicine, children and adolescents, lipids (amino acids, peptides, and proteins), Female, medicine.drug, Adult, Children and adolescents, Adolescent, Genotype, Population, Hyperlipidemias, Models, Biological, Modelling, modelling, 03 medical and health sciences, Young Adult, Pharmacokinetics, medicine, Humans, cardiovascular diseases, Dosing, education, CYP3A5, Active metabolite, business.industry, organic chemicals, nutritional and metabolic diseases, Pharmacokinetics and Disposition, chemistry, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, SLCO1B1, business