UCP2 expression is associated with weight loss after hypocaloric diet intervention
| العنوان: | UCP2 expression is associated with weight loss after hypocaloric diet intervention |
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| المؤلفون: | Wilson Salgado Junior, Carla Barbosa Nonino, Carolina Ferreira Nicoletti, Cristiana Cortes-Oliveira, Julio Sérgio Marchini, B. A. P. de Oliveira, W A da Silva Júnior, Driele Cristina Gomes Quinhoneiro, Natália Yumi Noronha, M A de Souza Pinhel |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Vitamin, Waist, Calorie, Diet, Reducing, Medicine (miscellaneous), Physiology, 030209 endocrinology & metabolism, Body Mass Index, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Weight loss, Statistical significance, Weight Loss, Humans, Medicine, Uncoupling Protein 2, Longitudinal Studies, Obesity, Uncoupling Protein 1, Nutrition and Dietetics, business.industry, Middle Aged, medicine.disease, Obesity, Morbid, 030104 developmental biology, Gene Expression Regulation, chemistry, Receptors, Adrenergic, beta-3, Multivariate Analysis, Basal metabolic rate, Body Composition, Linear Models, Female, Basal Metabolism, Waist Circumference, medicine.symptom, business, Body mass index, ESTUDOS LONGITUDINAIS |
| الوصف: | Although energy restriction contributes to weight loss, it may also reduce energy expenditure, limiting the success of weight loss in the long term. Studies have described how genetics contributes to the development of obesity, and uncoupling proteins 1 and 2 (UCP1 and UCP2) and beta-3-adrenoceptor (ADRB3) have been implicated in the metabolic pathways that culminate in this condition. This study aimed to evaluate how the UCP1, UCP2 and ADRB3 genes influence weight loss in severely obese women submitted to hypocaloric dietary intervention. This longitudinal study included 21 women divided into two groups: Group 1 (Dietary intervention (G1)) consisted of 11 individuals with severe obesity (body mass index (BMI) ⩾40 kg/m2), selected for dietary intervention and Group 2 (Control (G2)) consisted of 10 normal-weight women (BMI between 18.5 and 24.9 kg/m2). Evaluation included weight (kg), height (m), waist circumference (cm), body composition, resting metabolic rate (RMR, kcal) and abdominal subcutaneous adipose tissue collection. The dietary intervention required that G1 patients remained hospitalized in the university hospital for 6 weeks receiving a hypocaloric diet (1200 kcal per day). The statistical analyses included t-test for paired samples, Spearman correlation and multivariate linear regressions, with the level of significance set at P |
| تدمد: | 1476-5640 0954-3007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd18b8511f9d27d68eee8ffcacd698a7Test https://doi.org/10.1038/ejcn.2016.185Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd18b8511f9d27d68eee8ffcacd698a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765640 09543007 |
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