Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans
| العنوان: | Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans |
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| المؤلفون: | Ji Cheng, Thomas M.S. Wolever, Judlyn Fernandes, Sari Rahat-Rozenbloom |
| المصدر: | European journal of clinical nutrition |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Calorie, Medicine (miscellaneous), Overweight, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Glucagon-Like Peptide 1, Single-Blind Method, 2. Zero hunger, Cross-Over Studies, Nutrition and Dietetics, digestive, oral, and skin physiology, Inulin, food and beverages, Starch, Middle Aged, Postprandial Period, Ghrelin, Dietary-Fibre, Female, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, gut hormone, Adult, Vitamin, medicine.medical_specialty, GLP 1, 030209 endocrinology & metabolism, Article, Short-chain fatty acids, 03 medical and health sciences, Thinness, Internal medicine, Appetite Depressants, microbiota, medicine, Humans, Peptide YY, 030109 nutrition & dietetics, PYY, obese, business.industry, nutritional and metabolic diseases, Metabolism, Fatty Acids, Volatile, medicine.disease, Obesity, Gastrointestinal Microbiome, Lunch, Prebiotics, Endocrinology, chemistry, Fermentation, business |
| الوصف: | Background Colonic fermentation of dietary-fibre to short-chain-fatty-acids (SCFA) influences appetite hormone secretion in animals, but SCFA production is excessive in obese animals. This suggests there may be resistance to the effect of SCFA on appetite-hormones in obesity. Objectives to determine the effects of inulin (IN) and resistant-starch (RS) on postprandial SCFA, and gut hormone (GLP-1, PYY, and ghrelin) responses in healthy overweight/obese (OWO) vs lean (LN) humans. Methods Overnight fasted participants (13 OWO, 12 LN) consumed 300mL water containing 75g glucose (GLU) as Control, or 75g glucose plus 24g IN, or 28.2g RS using a randomized, single-blind, cross-over design. Blood for appetite-hormones and SCFA was collected at intervals over 6h. A standard lunch was served 4h after the test drink. Results Relative to GLU, IN, but not RS, significantly increased SCFA AUC from 4–6h (AUC4-6). Neither IN nor RS affected GLP-1 or PYY-AUC4-6. Although neither IN nor RS reduced ghrelin-AUC4-6 compared to GLU, ghrelin at 6h after IN was significantly lower than that after GLU (p |
| تدمد: | 1476-5640 0954-3007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71a21a4eef7b6b318168a208d9747a0Test https://doi.org/10.1038/ejcn.2016.249Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b71a21a4eef7b6b318168a208d9747a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765640 09543007 |
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