Impairment of Growth Hormone and Insulin Secretion in Hyperthyroidism
| العنوان: | Impairment of Growth Hormone and Insulin Secretion in Hyperthyroidism |
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| المؤلفون: | U. Raggi, F. Cavagnini, Maddalena Peracchi, A. Malinverni, R. Bana, M. Pinto, Antonio E. Pontiroli |
| المصدر: | European Journal of Clinical Investigation. 4:71-77 |
| بيانات النشر: | Wiley, 1974. |
| سنة النشر: | 1974 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Arginine, medicine.medical_treatment, Clinical Biochemistry, Thyroid Gland, Thyroid Function Tests, Biology, Hypoglycemia, Hyperthyroidism, Biochemistry, Thyroid function tests, Impaired glucose tolerance, Catecholamines, Internal medicine, Insulin Secretion, medicine, Humans, Insulin, Aged, Glucose tolerance test, medicine.diagnostic_test, General Medicine, Glucose Tolerance Test, Middle Aged, medicine.disease, Growth hormone secretion, Endocrinology, Growth Hormone, Pituitary Gland, Catecholamine, Female, medicine.drug |
| الوصف: | The pattern of growth hormone (GH) and im-munoreactive insulin (IRI) secretion in response to insulin hypoglycaemia, arginine infusion and oral glucose load has been investigated in a group of hyperthyroid subjects. In twenty patients, compared with twenty normal controls, GH secretion was significantly reduced in response to both insulin hypoglycaemia and arginine infusion. Arginine-induced IRI secretion was also clearly decreased. In ten patients who had undergone a 100 g oral glucose load, hyperglycaemia failed to suppress GH levels, which increased paradoxically. Slightly impoverished IRI secretion and impaired glucose tolerance were observed in these subjects. In five patients, re-examined soon after restoration of euthyroidiszn, no significant changes in glucose tolerance and IRI secretion were noted; instead, a slightly improved GH response to the provocative stimuli and the restoration of a normal GH suppression by glucose were observed. – The possibility is emphasized that in hyperthyroidism an enhancement of the catecholamine effect induced by thyroid hormones is involved in the diminished GH and IRI secretion. |
| تدمد: | 1365-2362 0014-2972 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26106626cf4444e7de90f83be7715177Test https://doi.org/10.1111/j.1365-2362.1974.tb00375.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....26106626cf4444e7de90f83be7715177 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652362 00142972 |
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