Glycaemic control and in vivo non-oxidative Maillard reaction: urinary excretion of pyrraline in diabetes patients
| العنوان: | Glycaemic control and in vivo non-oxidative Maillard reaction: urinary excretion of pyrraline in diabetes patients |
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| المؤلفون: | Merce Bergua, Reinald Pamplona, Joan Prat, Maria Josep Bellmunt, M. Portero-Otin |
| المصدر: | ResearcherID Scopus-Elsevier |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Adolescent, Urinary system, Matched-Pair Analysis, Clinical Biochemistry, Population, Renal function, Urine, Biochemistry, chemistry.chemical_compound, Diabetes mellitus, Internal medicine, Norleucine, medicine, Humans, Urea, Pyrroles, education, Child, Chromatography, High Pressure Liquid, Aged, Aged, 80 and over, Glycated Hemoglobin, Creatinine, education.field_of_study, General Medicine, Middle Aged, medicine.disease, Maillard Reaction, Fructosamine, Endocrinology, Diabetes Mellitus, Type 1, chemistry, Metabolic control analysis, Regression Analysis, Female |
| الوصف: | The presence of pyrraline in human urine has recently been described. Using reversed-phase high-performance liquid chromatography, we measured urinary pyrraline in 45 insulin-treated diabetic patients with preserved renal function and in 30 age- and sex-matched healthy subjects. The relationship between urinary pyrraline and metabolic control parameters in the diabetic population (glycaemia, fructosamine, haemoglobin Al c , and 1-year mean haemoglobin A1 c ) was evaluated. The mean urinary level of pyrraline in diabetic patients with poor glycaemic control (HbA 1c > 9.5%) was higher than that in healthy subjects (1.12 ± 0.35 vs. 075 ± 0.2 μmol mmol -1 creatinine, P< 0.04), whereas in patients with good to moderate glycaemic control (HbA1 c < 9.5) it was slightly but not significantly higher than in healthy subjects (0.80 ± 0.3 μmol mmol -1 creatinine vs. 0.75 ± 0.2 μmol mmol -1 creatinine). There is a significant correlation between urinary pyrraline level and glycaemia (P < 0.008), haemoglobin A1 c (P < 0.01) and 1-year mean haemoglobin Al c values (P |
| تدمد: | 0014-2972 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b64e926adb26ec6029b49fc9c3dea9Test https://pubmed.ncbi.nlm.nih.gov/9352249Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a2b64e926adb26ec6029b49fc9c3dea9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00142972 |
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