Endoscopic endoclip papilloplasty preserves sphincter of oddi function
| العنوان: | Endoscopic endoclip papilloplasty preserves sphincter of oddi function |
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| المؤلفون: | Hong Chang, Yonghui Huang, Yaopeng Zhang, Ke Li, Wei Yao, Yingchun Wang, Xiue Yan, Hejun Zhang, Kun Wang, Lingyu Meng |
| المصدر: | European Journal of Clinical Investigation. 51 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Ampulla of Vater, medicine.medical_specialty, Contraction (grammar), Manometry, Sus scrofa, Clinical Biochemistry, Urology, 030204 cardiovascular system & hematology, Biochemistry, Sphincterotomy, Endoscopic, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Sphincter of Oddi, Animals, Medicine, 030212 general & internal medicine, Muscle actin, Common bile duct, business.industry, General Medicine, Plastic Surgery Procedures, Surgical Instruments, medicine.disease, Actins, Endoclip, Major duodenal papilla, medicine.anatomical_structure, Sphincter of Oddi Dysfunction, Sphincter of Oddi dysfunction, Fibrous repair, business |
| الوصف: | Background Endoscopic sphincterotomy (EST) can destroy sphincter of Oddi (SO) structure and function. The purpose of this study was to assess the feasibility of endoscopic endoclip papilloplasty (EEPP) in restoring SO function after EST. Methods Seven 26-week-old domestic pigs were divided into control and EEPP groups. Necropsy and haematoxylin-eosin staining plus anti-α-smooth muscle actin (α-SMA) staining of papilla and sphincter of Oddi manometry (SOM) were conducted in animals at three independent time points. Results EST and EEPP were safely performed in all 7 pigs without serious adverse events. For primary outcome, compared to the controls, EEPP generated smaller dilation and less inflammation. Fibrous repair of the papilla was observed at 24 weeks after EEPP. For secondary outcome, in the control group, SO basal pressure (17.25 ± 18.14 to 5.50 ± 0.71 mmHg), SO contraction amplitude (46.00 ± 19.20 to 34.50 ± 48.79 mmHg), peak (4.50 ± 4.04 to 1.50 ± 2.12) and frequency (3.05 ± 3.29 to 1.41 ± 2.19/min) were reduced after EST. Further reductions to almost 0 of these SOM parameters were observed 3 weeks later, including common bile duct pressure and SO contraction period. In contrast, in the EEPP group, these manometric data were recovered to pre-EST levels, including CBD pressure (11.5 ± 7.31 vs 11 ± 2.16 mmHg), SO pressure (17.50 ± 17.75 vs 18.20 ± 21.39 mmHg) and SO contraction amplitude (53.67 ± 21.54 vs 60.00 ± 36.08 mmHg). However, no significant differences were observed between control and EEPP groups by Student t test. Conclusions In this porcine study, EEPP accelerated and improved papillary healing after EST, further preserved SO function. |
| تدمد: | 1365-2362 0014-2972 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8414b7da25a902dfa12e2fb8b89b4bdeTest https://doi.org/10.1111/eci.13408Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8414b7da25a902dfa12e2fb8b89b4bde |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652362 00142972 |
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