التفاصيل البيبلوغرافية
| العنوان: |
Correlation between rheumatoid arthritis and periodontitis. |
| المؤلفون: |
Zielińska, Anna, Tabarkiewicz, Jacek |
| المصدر: |
European Journal of Clinical & Experimental Medicine; 2022, Vol. 20 Issue 4, p451-458, 8p |
| مصطلحات موضوعية: |
RHEUMATOID arthritis, PERIODONTITIS, PATHOGENIC microorganisms, PORPHYROMONAS gingivalis, ORAL diseases |
| مستخلص: |
Introduction and aim. The association between periodontitis (PD) and rheumatoid arthritis (RA) has been analyzed and described in literature. Periodontal pathogens, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are pointed as the common factors for both diseases. In this work we demonstrate that treatment of dental and oral diseases is an unconditional requirement for patients with RA. Material and methods. PubMed was searched with the keyword "rheumatoid arthritis" and "periodontitis" from May 1999 to January 2022, showed 181 articles. Ultimately 72 articles were included in the review. Analysis of the literature. The above mentioned pathogens exhibit multiple mechanisms that disturb immune and inflammatory responses of the human organism. Those mechanisms lead to the periodontal disease (PD) that may activate the systematic reactions which in turn lead to intensification of systematic diseases such as rheumatoid arthritis (RA). P. gingivalis has the ability to expresses PAD enzyme (peptidylarginine deiminase) and activates the citrullization process. Moreover, the bacterium produces gingipain cysteine proteinases, which degrade the mechanisms of immunological system. The latter pathogen, A. actinomycetemcomitans, expresses hypercitrullization in neutrophils. Conclusion. Both pathogens influence inflammatory response of the organism, through the common pro-inflammatory mediators for periodontitis and rheumatoid arthritis, intensify the clinical manifestations of both diseases. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Clinical & Experimental Medicine is the property of University of Rzeszow and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
