التفاصيل البيبلوغرافية
| العنوان: |
Sublobar resection is not always superior for early-stage lung cancer in high-risk patients. |
| المؤلفون: |
Fukui, Mariko, Matsunaga, Takeshi, Hattori, Aritoshi, Takamochi, Kazuya, Nojiri, Shuko, Suzuki, Kenji |
| المصدر: |
European Journal of Cardio-Thoracic Surgery; Jan2024, Vol. 65 Issue 1, p1-7, 7p |
| مصطلحات موضوعية: |
LUNG cancer, CLINICAL trials, CANCER patients, CARCINOEMBRYONIC antigen, LUNG volume measurements |
| مستخلص: |
Open in new tab Download slide OBJECTIVES The phase III trial, Japan Clinical Oncology Group 0802, illustrated the superiority of sublobar resection for early-stage lung cancer in terms of overall survival, with more non-lung cancer-related deaths after a lobectomy. The advantages of sublobar resection may be more pronounced in high-risk patients. The goal of this study was to elucidate the prognoses of high-risk patients. METHODS Patients with a risk of being ineligible for Japan Clinical Oncology Group 0802 for general conditions were classified as the high-risk group, and those who were not at risk of being ineligible were classified as the normal-risk group. Overall survival and prognostic factors were analysed in the high-risk group. RESULTS There were 254 (19.4%) and 1054 patients in the high- and normal-risk groups, respectively. Five-year survival rates were 94.5% and 79.1% in the normal-risk and high-risk groups, respectively (P < 0.001). More patients in the high-risk group died of lung cancer (P < 0.001) and non-lung cancer deaths (P < 0.001) than patients in the normal-risk group. In the high-risk group, 151 lobectomies and 103 sublobar resections were performed. There was no significant difference in the numbers of lung cancer deaths and of non-lung cancer deaths between the procedures. Stratified survival analyses showed that the diffusing capacity of the lungs for carbon monoxide < 40% tended to favour sublobar resection; being female and having a high carcinoembryonic antigen level tended to favour a lobectomy. CONCLUSIONS Sublobar resection is not always superior for early-stage lung cancer. Even in such cases, the surgical method should be determined by taking into consideration the patient's background and lung cancer surveillance. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
