The prevalence of Epstein-Barr virus (EBV) markers in nodal lesions from Algerians (AI) patients (n = 68) was compared to French (Fr) patients (Pts) (n = 21) with Hodgkin's disease. Initial characteristics were: males Fr 57%, AI 53%; median age Fr 29, AI 25; histologic subtypes: lymphocytic predominance (LP) Fr I, AI 3; nodular sclerosis (NS) Fr 16, AI 33; mixed cellularity (MC) Fr 4, AI 30; lymphocytic depletion (LD) A12. The latent membrane protein (LMP) expression was founded in Reed-Sternberg cells (RSC) in 26 cases AI (I PL, 8 NS, 17 MC) and 4 Fr (2 NS, 2 MC). All cases LMP-positive were also by DNAor RNA in situ hybridization (ISH). ISH was positive in RSC of 29% of Fr and 66% of AI Pts (P More pronounced ISH positivity in AI young adult cases (P
