Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease
| العنوان: | Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease |
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| المؤلفون: | Lone Sunde, Kirsty Balanchandran, Minke Frijstein, Georgia Mangili, Sileny Han, Miguel Henriques Abreu, Nataliya Tsip, Anneke M. Westermann, Vilmos Fulop, Franziska Siegenthaler, Michael J. Seckl, Manuela Undurraga, John Coulter, Anne Hills, Angela Salerno, Kamaljit Singh, Lotte Boog, Jacob Korach, Nelleke Ottevanger, Jérôme Massardier, Ulrika Joneborg, Eva Maria Roes, Frédéric Goffin, Luisa Skupin, Fernando Manuel Ribeiro Gomes, Alice Bergamini, Jane Ireson, Benoit You, Catriona Kenneally, Miroslav Korbel, Saša Kadija, Vildana Finci, Isa Niemann, Sarah Delcominette, Antonio Casado, Gloria Marquina, Pierre Adrien Bolze, Grzegorz Szewczyk, François Golfier, Nienke E. van Trommel, Naveed Sarwar, Raffaella Cioffi, Cantù Maria Grazia, Patrick Chien, John Tidy, Christianne A.R. Lok, Gitta Turowski, Yalck K. Eysbouts, Su Harma, Ginette Rosseel, Ulrike Meyer-Hamme, Erika Utracka, Jocelyne Attia, Mehmet Harma, Olesya Solheim, Matthew C Winter, Jean Pierre Lotz, Vesna Kesic, Sophie Patrier, Muge Harma, Janne Kaern, Magdalena Miedzińska, Sinan Ozalp, Eva-Maria Grischke, Amit Mayer, Leigh Bowman, Emelie Wallin, Hind Hamad Elmalik, Leon F.A.G. Massuger |
| المساهمون: | Oncology, CCA - Cancer Treatment and Quality of Life |
| المصدر: | European Journal of Cancer, 130, pp. 228-240 European journal of cancer (Oxford, England, 130, 228-240. Elsevier Limited European Journal of Cancer, 130, 228-240 |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, Consensus, Gestational trophoblastic disease, Referral, Guidelines as Topic, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Pregnancy, medicine, Humans, Intensive care medicine, Placental site trophoblastic tumor, Gestational trophoblastic neoplasia, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Heterogeneous group, business.industry, Optimal treatment, Referral and consultation, medicine.disease, Optimal management, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Patient management, Europe, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, business |
| الوصف: | Background and aim Gestational trophoblastic disease (GTD) is a heterogeneous group of disorders characterised by abnormal proliferation of trophoblastic tissue. Since GTD and its malignant sequel gestational trophoblastic neoplasia (GTN) are rare diseases, little evidence is available from randomised controlled trials on optimal treatment and follow-up. Treatment protocols vary within Europe, and even between different centres within countries. One of the goals of the ‘European Organisation for Treatment of Trophoblastic Diseases’ (EOTTD) is to harmonise treatment in Europe. To provide a basis for European standardisation of definitions, treatment and follow-up protocols in GTD, we composed a set of guidelines for minimal requirements and optimal management of GTD. Methods Members from each EOTTD country attended multiple workshops during annual EOTTD meetings. Clinical guidelines were formulated by consensus and evidence where available. The following guidelines were discussed: diagnostics of GTD and GTN, treatment of low-risk GTN, high-risk GTN, ultra-high-risk GTN, placental site and epithelioid trophoblastic tumours and follow-up. Results Between 40 and 65 EOTTD members from 17 European countries and 7 non-European countries attended the clinical workshops held on 6 occasions. Flow diagrams for patient management were composed to display minimum and best practice for most treatment situations. New agreed definitions of recurrence and chemotherapy resistance were formulated. Conclusions Despite the many differences between and within the participating countries, an important step in uniform treatment of GTD and GTN within Europe was made by the Clinical Working Party of the EOTTD. This is an example on how guidelines and harmonisation can be achieved within international networks. |
| وصف الملف: | application/pdf |
| تدمد: | 0959-8049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab23634d44abe60e1e45d9c3bd4af6ddTest https://doi.org/10.1016/j.ejca.2020.02.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ab23634d44abe60e1e45d9c3bd4af6dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09598049 |
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