Eicosapentaenoic acid restrains the development of the cardiovascular events independent of triglyceride and C-reactive protein reduction in Japanese hemodialysis patients
| العنوان: | Eicosapentaenoic acid restrains the development of the cardiovascular events independent of triglyceride and C-reactive protein reduction in Japanese hemodialysis patients |
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| المؤلفون: | M. End, Y. Iwabuchi, N. Maeda, M. Suzuki, K. Seino, F. Yamauchi, M. Nasu, M. Ohsawa, Y. Tamura |
| المصدر: | European Heart Journal. 34:P1428-P1428 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, C-reactive protein, medicine.disease, Eicosapentaenoic acid, law.invention, Coronary artery disease, Randomized controlled trial, law, Internal medicine, medicine, Cardiology, biology.protein, Myocardial infarction, Hemodialysis, Cardiology and Cardiovascular Medicine, business, Survival rate, Dialysis |
| الوصف: | Backgrounds: It is well known that eicosapentaenoic acid (EPA) contributes to secondary prevention of coronary artery disease. Hemodialysis (HD) patients have a high incidence of cardiovascular disease and inceased mortality. However, whether EPA decreases risks of cardiovascular morbidity and mortality has not been elucidated in HD patients. Methods: A prospective, randomized, open-label controlled trial was carried out in our dialysis institute since 2010. A total of 89 hemodialysis patients were randomly allocated into intervention group (receiving 1800 mg/day of EPA) and 90 patients were allocated into control group. Patients followed for 2 years. Outcomes were all-cause and cardiovascular death, cardiovascular events (acute myocardial infarction, stroke and aortic disease-related event) and a combined-outcome (CO) of all-cause death and cardiovascular events. Results: Baseline characteristics and outcome results were shown in the table. Both the survival rate and the event-free rate from CO in the intervention group were significantly higher than those in controls. The C-reactive protein level and triglyceride at the beginning and at the end of the trial was not different between two groups statistically. View this table: Baseline characteristics and outcome Conclusion: EPA significantly contributes to decline in risks of cardiovascular morbidity and mortality in HD patients independent of triglyceride and C-reactive protein reduction. |
| تدمد: | 1522-9645 0195-668X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::2bf9844fb23602c3fcecb33a5051c47fTest https://doi.org/10.1093/eurheartj/eht308.p1428Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........2bf9844fb23602c3fcecb33a5051c47f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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