Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study
| العنوان: | Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study |
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| المؤلفون: | Naoyuki Katagiri, Masafumi Mizuno, Kazunori Matsumoto, Hidenori Yamasue, Kiyoto Kasai, Chika Obara, Atsushi Furuichi, Mihoko Nakamura, Yumiko Nishikawa, Atsushi Sakuma, Mikio Kido, Tsutomu Takahashi, Kyo Noguchi, Yoichiro Takayanagi, Daiki Sasabayashi, Shinsuke Koike, Michio Suzuki |
| المصدر: | European Archives of Psychiatry and Clinical Neuroscience. 269:397-406 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Risk, Psychosis, Adolescent, Prefrontal Cortex, Prodromal Symptoms, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Pharmacology (medical), Biological Psychiatry, Orbital Sulcus, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, General Medicine, Anatomy, medicine.disease, Magnetic Resonance Imaging, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, Multicenter study, Schizophrenia, Mental state, Disease Progression, Female, Orbitofrontal cortex, Gross morphology, business, 030217 neurology & neurosurgery |
| الوصف: | Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. The ARMS group as a whole had a significantly lower number of intermediate and posterior orbital sulci compared with the controls, which was associated with prodromal symptomatology. However, there was no group difference in OFC pattern distribution. The ARMS-P and -NP groups did not differ in OFC surface morphology. These results suggest that gross morphology of the OFC in high-risk subjects may at least partly reflect neurodevelopmental pathology related to vulnerability to psychosis. |
| تدمد: | 1433-8491 0940-1334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac7989b02f40760cfc98d371d59a7b8Test https://doi.org/10.1007/s00406-018-0890-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0ac7989b02f40760cfc98d371d59a7b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14338491 09401334 |
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