Sex-related differences in risk factors, outcome, and quality of life in patients with permanent atrial fibrillation
| العنوان: | Sex-related differences in risk factors, outcome, and quality of life in patients with permanent atrial fibrillation |
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| المؤلفون: | Michiel Rienstra, Harry J.G.M. Crijns, Isabelle C. Van Gelder, Dirk J. van Veldhuisen, Hessel F. Groenveld, Bart A. Mulder, Mariëlle Kloosterman |
| المساهمون: | Cardiovascular Centre (CVC), MUMC+: MA Cardiologie (9), Cardiologie, RS: Carim - H01 Clinical atrial fibrillation |
| المصدر: | Europace, 22(11), 1619-1627. Oxford University Press EP Europace, 22(11), 1619-1627. Oxford University Press |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, FEMALE SEX, Population, BIOMARKERS, GUIDELINES, Coronary artery disease, Quality of life, Heart Rate, Physiology (medical), Internal medicine, Atrial Fibrillation, Sex differences, Permanent atrial fibrillation, Humans, Medicine, Risk factor, education, Stroke, Sex Characteristics, education.field_of_study, business.industry, Predictors, DEATH, Atrial fibrillation, medicine.disease, Prognosis, COMMUNITY, Risk factors, Heart failure, Quality of Life, Female, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, business, Substrate, STROKE |
| الوصف: | Aims Atrial fibrillation (AF) risk factors translate into disease progression. Whether this affects women and men differently is unclear. We aimed to investigate sex differences in risk factors, outcome, and quality of life (QoL) in permanent AF patients. Methods and results The Rate Control Efficacy in Permanent Atrial Fibrillation (RACE II) randomized 614 patients, 211 women and 403 men, to lenient or strict rate control. In this post hoc analysis risk factors, cardiovascular events during 3-year follow-up (cardiovascular death, heart failure hospitalization, stroke, systemic embolism, bleeding, and life-threatening arrhythmic events), outcome parameters, and QoL were compared between the sexes. Women were older (71 ± 7 vs. 66 ± 8 years, P Conclusion In this permanent AF population, women had more accumulation of AF risk factors than men. The observed higher cardiovascular event rate in women was no longer significant after adjusting for the number of risk factors. Further, QoL was negatively influenced by the higher number of risk factors in women. This suggests that sex differences may be driven by the greater risk factor burden in women. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1099-5129 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed1a3bbaa99769151d8838bac668946Test https://hdl.handle.net/11370/416df26d-e1e0-4a99-aee8-db1e6c325c94Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eed1a3bbaa99769151d8838bac668946 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10995129 |
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