Sacubitril/valsartan in patients listed for heart transplantation: effect on physical frailty
| العنوان: | Sacubitril/valsartan in patients listed for heart transplantation: effect on physical frailty |
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| المؤلفون: | Valentina Mercurio, Vittorio Palmieri, Ciro Maiello, Pasquale Abete, Claudio Napoli, Giuditta Benincasa, Francesco Cacciatore, Gemma Salerno, Flora Pirozzi, Cristiano Amarelli, Marco Di Maio, Domenico Bonaduce, Paolo Golino, Irene Mattucci, Francesco Curcio |
| المساهمون: | Cacciatore, F., Amarelli, C., Maiello, C., Mattucci, I., Salerno, G., Di Maio, M., Palmieri, V., Curcio, F., Pirozzi, F., Mercurio, V., Benincasa, G., Golino, P., Bonaduce, D., Napoli, C., Abete, P. |
| المصدر: | ESC Heart Failure ESC Heart Failure, Vol 7, Iss 2, Pp 757-762 (2020) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Short Communication, medicine.medical_treatment, Short Communications, 030204 cardiovascular system & hematology, Ventricular Function, Left, Sacubitril, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Diseases of the circulatory (Cardiovascular) system, Humans, 030212 general & internal medicine, Pulmonary wedge pressure, Heart Failure, Heart transplantation, Ejection fraction, Frailty, business.industry, Aminobutyrates, Biphenyl Compounds, Stroke Volume, Sacubitril/Valsartan, medicine.disease, Drug Combinations, Blood pressure, Valsartan, RC666-701, Heart failure, Cardiology, Heart Transplantation, Cardiology and Cardiovascular Medicine, business, human activities, Sacubitril, Valsartan, medicine.drug |
| الوصف: | Aims The aim of this study was to investigate prospectively the effect of sacubitril/valsartan in advanced heart failure (HF) patients in waiting list for heart transplantation (HT) and the effect on physical frailty (PF). Methods and results We treated 37 consecutive patients with advanced HF with sacubitril/valsartan. Patients were followed up until HT, device implant, or last follow‐up visit after 2 years of follow‐up. At baseline, mean New York Heart Association (NYHA) class was 3.1 ± 0.4, with 64.9% in NYHA III and 35.1% NYHA IIIB. Left ventricular ejection fraction was 23.5 ± 5.8%, VO2 max was 10.3 ± 2.3 mL/kg/min, cardiac index was 2.3 ± 0.5 L/min/m2, and N‐terminal pro‐brain natriuretic peptide (NT‐pro‐BNP) was 4943.0 ± 5326.8 pg/mL. After a mean follow‐up of 17.1 ± 4.4 months, no deaths were observed, but NYHA class improved significantly with 56.8% in NYHA II, 40.5% in NYHA III, and 2.7% in NYHA IIIB (P < 0.001). VO2 max and 6 min walk test (6MWT) increased, whereas pulmonary systolic blood pressure, E/E′, VE/VCO2 slope, and NT‐pro‐BNP decreased. At right heart catheterization performed after 1 year of follow‐up, cardiac index and pulmonary vascular resistance remained stable, while a decrease in systolic pulmonary artery pressure and pulmonary capillary wedge pressure is observed. Furosemide dosage decrease from 102.7 ± 69.4 to 78.7 ± 66.3 mg (P = 0.040). PF decreased from 3.35 ± 1.0 at baseline to 1.57 ± 1.3 at the end of follow‐up (P < 0.001), with a reduction in all PF domains. Conclusions Our study showed a rapid improvement in PF in HT waiting list patients treated with sacubitril/valsartan. The improvement in all PF domains was paralleled by VO2 and 6MWT increase and together with an NT‐pro‐BNP reduction constant over the follow‐up. |
| تدمد: | 2055-5822 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ed0978d9b1768bffa66ed9502f9d62Test https://doi.org/10.1002/ehf2.12610Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26ed0978d9b1768bffa66ed9502f9d62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20555822 |
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